Immunosuppressants and risk of Parkinson disease

Brad A. Racette; Anat Gross; Scott Martin Vouri; Alejandra Camacho‐Soto; Allison W. Willis; Susan Searles Nielsen

doi:10.1002/acn3.580

journal article Open Access May 31, 2018

Immunosuppressants and risk of Parkinson disease

Brad A. Racette Anat Gross Scott Martin Vouri Alejandra Camacho‐Soto Allison W. Willis

Susan Searles Nielsen

Annals of Clinical and Translational Neurology Vol. 5 No. 7 pp. 870-875 · Wiley

View at Publisher Save 10.1002/acn3.580

Abstract

AbstractWe performed a population‐based case–control study of United States Medicare beneficiaries age 60–90 in 2009 with prescription data (48,295 incident Parkinson disease cases and 52,324 controls) to examine the risk of Parkinson disease in relation to use of immunosuppressants. Inosine monophosphate dehydrogenase inhibitors (relative risk = 0.64; 95% confidence interval 0.51–0.79) and corticosteroids (relative risk = 0.80; 95% confidence interval 0.77–0.83) were both associated with a lower risk of Parkinson disease. Inverse associations for both remained after applying a 12‐month exposure lag. Overall, this study provides evidence that use of corticosteroids and inosine monophosphate dehydrogenase inhibitors might lower the risk of Parkinson disease.

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Details

Published: May 31, 2018
Vol/Issue: 5(7)
Pages: 870-875
License: View

Authors

B

Brad A. Racette

Department of Neurology Washington University School of Medicine 660 South Euclid Avenue, Campus Box 8111 St. Louis Missouri 63110; School of Public Health Faculty of Health Sciences University of the Witwatersrand 7 York Road Parktown 2193 South Africa

A

Anat Gross

Department of Neurology Washington University School of Medicine 660 South Euclid Avenue, Campus Box 8111 St. Louis Missouri 63110

S

Scott Martin Vouri

Center for Health Outcomes Research and Education Department of Pharmacy Practice St. Louis College of Pharmacy 4588 Parkview Place St. Louis Missouri 63110

A

Alejandra Camacho‐Soto

Department of Neurology Washington University School of Medicine 660 South Euclid Avenue, Campus Box 8111 St. Louis Missouri 63110

A

Allison W. Willis

Department of Neurology University of Pennsylvania Perelman School of Medicine 423 Guardian Drive Philadelphia Pennsylvania 19104; Department of Biostatistics, Epidemiology and Informatics University of Pennsylvania Perelman School of Medicine 423 Guardian Drive Philadelphia Pennsylvania 19104; The Center for Pharmacoepidemiology Research and Training University of Pennsylvania Perelman School of Medicine 423 Guardian Drive Philadelphia Pennsylvania 19104

S

Susan Searles Nielsen

Department of Neurology Washington University School of Medicine 660 South Euclid Avenue, Campus Box 8111 St. Louis Missouri 63110

Funding

National Institute of Neurological Disorders and Stroke Award: R01NS099129

National Institute of Environmental Health Sciences Award: K24ES017765

University of Pennsylvania

American Parkinson's Disease Foundation

Cite This Article

Brad A. Racette, Anat Gross, Scott Martin Vouri, et al. (2018). Immunosuppressants and risk of Parkinson disease. Annals of Clinical and Translational Neurology, 5(7), 870-875. https://doi.org/10.1002/acn3.580

Immunosuppressants and risk of Parkinson disease

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