Peripheral Nerve Regeneration: Current Status and New Strategies Using Polymeric Materials

Ana C. Pinho; Ana C. Fonseca; Arménio C. Serra; José D. Santos; Jorge F. J. Coelho

doi:10.1002/adhm.201600236

journal article Sep 07, 2016

Peripheral Nerve Regeneration: Current Status and New Strategies Using Polymeric Materials

Ana C. Pinho Ana C. Fonseca

Arménio C. Serra José D. Santos Jorge F. J. Coelho

Advanced Healthcare Materials Vol. 5 No. 21 pp. 2732-2744 · Wiley

View at Publisher Save 10.1002/adhm.201600236

Abstract

Experiments concerning peripheral nerve regeneration have been reported since the end of the 19th century. The need to implement an effective surgical procedure in terms of functional recovery has resulted in the appearance of several approaches to solve this problem. Nerve autograft was the first approach studied and is still considered the gold standard. Since autografts require donor harvesting, other strategies involving the use of natural materials have also been studied. Nevertheless, the results were not very encouraging and attention has moved towards the use of nerve conduits made from polymers, whose properties can be easily tailored and which allow the nerve conduit to be easily processed into a variety of shapes and forms. Some of these materials are already approved by the US Food and Drug Administration (FDA), as is presented here. Furthermore, polymers with conductive properties have very recently been subject to intensive study in this field, since it is believed that such properties have a positive influence in the regeneration of the new axons. This manuscript intends to give a global view of the mechanisms involved in peripheral nerve regeneration and the main strategies used to recover motor and sensorial function of injured nerves.

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Citations

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References

Details

Published: Sep 07, 2016
Vol/Issue: 5(21)
Pages: 2732-2744
License: View

Authors

A

Ana C. Pinho

CEMUC Department of Chemical Engineering University of Coimbra Rua Sílvio Lima‐Pólo II 3030–790 Coimbra Portugal

A

Ana C. Fonseca

CEMUC Department of Chemical Engineering University of Coimbra Rua Sílvio Lima‐Pólo II 3030–790 Coimbra Portugal

A

Arménio C. Serra

CEMUC Department of Chemical Engineering University of Coimbra Rua Sílvio Lima‐Pólo II 3030–790 Coimbra Portugal

J

José D. Santos

CEMUC Department of Metallurgical and Materials Engineering University of Porto Rua Dr Roberto Frias 4200–465 Porto Portugal

J

Jorge F. J. Coelho

CEMUC Department of Chemical Engineering University of Coimbra Rua Sílvio Lima‐Pólo II 3030–790 Coimbra Portugal

Funding

Fundo Regional para a Ciência e Tecnologia Award: PD/BD/52626/2014

Cite This Article

Ana C. Pinho, Ana C. Fonseca, Arménio C. Serra, et al. (2016). Peripheral Nerve Regeneration: Current Status and New Strategies Using Polymeric Materials. Advanced Healthcare Materials, 5(21), 2732-2744. https://doi.org/10.1002/adhm.201600236

Peripheral Nerve Regeneration: Current Status and New Strategies Using Polymeric Materials

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