Conjugated Oligoelectrolytes for Long‐Term Tumor Tracking with Incremental NIR‐II Emission

Zeshun Li; Ziyue Zhu; Geraldine W. N. Chia; Alexander Mikhailovsky; Ricardo Javier Vázquez; Samuel J. W. Chan; Kai Li; Bin Liu; Guillermo C. Bazan

doi:10.1002/adma.202201989

journal article Apr 18, 2022

Conjugated Oligoelectrolytes for Long‐Term Tumor Tracking with Incremental NIR‐II Emission

Zeshun Li Ziyue Zhu Geraldine W. N. Chia Alexander Mikhailovsky Ricardo Javier Vázquez

Advanced Materials Vol. 34 No. 20 · Wiley

View at Publisher Save 10.1002/adma.202201989

Abstract

AbstractThe design and synthesis of the near‐infrared (NIR)‐II emissive conjugated oligoelectrolyte COE‐BBT are reported. COE‐BBT has a solubility in aqueous media greater than 50 mg mL−1, low toxicity, and a propensity to intercalate lipid bilayers, wherein it exhibits a higher emission quantum yield relative to aqueous media. Addition of COE‐BBT to cells provides two emission channels, at ≈500 and ≈1020 nm, depending on the excitation wavelength, which facilitates in vitro confocal microscopy and in vivo animal imaging. The NIR‐II emission of COE‐BBT is used to track intracranial and subcutaneous tumor progression in mice. Of relevance is that the total NIR‐II intensity increases over time. This phenomenon is attributed to a progressive attenuation of a COE‐BBT self‐quenching effect within the cells due to the expected dye dilution per cell as the tumor proliferates.

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Metrics

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Citations

63

References

Details

Published: Apr 18, 2022
Vol/Issue: 34(20)
License: View

Authors

Z

Zeshun Li

Shenzhen Key Laboratory of Smart Healthcare Engineering Department of Biomedical Engineering Southern University of Science and Technology (SUSTech) Shenzhen 518055 China

Z

Ziyue Zhu

Department of Chemistry and Biochemistry Center for Polymers and Organic Solids University of California Santa Barbara Santa Barbara CA 93106 USA

G

Geraldine W. N. Chia

Department of Chemistry National University of Singapore Singapore 117543 Singapore; Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore 639798 Singapore

A

Alexander Mikhailovsky

Department of Chemistry and Biochemistry Center for Polymers and Organic Solids University of California Santa Barbara Santa Barbara CA 93106 USA

R

Ricardo Javier Vázquez

Department of Chemistry National University of Singapore Singapore 117543 Singapore

S

Samuel J. W. Chan

Department of Chemistry National University of Singapore Singapore 117543 Singapore

K

Kai Li

Shenzhen Key Laboratory of Smart Healthcare Engineering Department of Biomedical Engineering Southern University of Science and Technology (SUSTech) Shenzhen 518055 China

B

Bin Liu

Department of Chemical and Biomolecular Engineering National University of Singapore Singapore 117585 Singapore

G

Guillermo C. Bazan

Department of Chemistry National University of Singapore Singapore 117543 Singapore; Department of Chemical and Biomolecular Engineering National University of Singapore Singapore 117585 Singapore; Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore 639798 Singapore

Funding

National Natural Science Foundation of China Award: 31870991

National University of Singapore Award: R143‐000‐A97‐133

Cite This Article

Zeshun Li, Ziyue Zhu, Geraldine W. N. Chia, et al. (2022). Conjugated Oligoelectrolytes for Long‐Term Tumor Tracking with Incremental NIR‐II Emission. Advanced Materials, 34(20). https://doi.org/10.1002/adma.202201989

Conjugated Oligoelectrolytes for Long‐Term Tumor Tracking with Incremental NIR‐II Emission

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