Plant Natural Flavonoids Against Multidrug Resistant Pathogens

Meirong Song; Ying Liu; Tingting Li; Xiaojia Liu; Zhihui Hao; Shuangyang Ding; Pharkphoom Panichayupakaranant; Kui Zhu; Jianzhong Shen

doi:10.1002/advs.202100749

journal article Open Access May 26, 2021

Plant Natural Flavonoids Against Multidrug Resistant Pathogens

Meirong Song

Ying Liu

Tingting Li

Xiaojia Liu Zhihui Hao

Shuangyang Ding Pharkphoom Panichayupakaranant Kui Zhu

Jianzhong Shen

Advanced Science Vol. 8 No. 15 · Wiley

View at Publisher Save 10.1002/advs.202100749

Abstract

AbstractThe increasing emergence and dissemination of multidrug resistant (MDR) bacterial pathogens accelerate the desires for new antibiotics. Natural products dominate the preferred chemical scaffolds for the discovery of antibacterial agents. Here, the potential of natural flavonoids from plants against MDR bacteria, is demonstrated. Structure–activity relationship analysis shows the prenylation modulates the activity of flavonoids and obtains two compounds, α‐mangostin (AMG) and isobavachalcone (IBC). AMG and IBC not only display rapid bactericidal activity against Gram‐positive bacteria, but also restore the susceptibility of colistin against Gram‐negative pathogens. Mechanistic studies generally show such compounds bind to the phospholipids of bacterial membrane, and result in the dissipation of proton motive force and metabolic perturbations, through distinctive modes of action. The efficacy of AMG and IBC in four models associated with infection or contamination, is demonstrated. These results suggest that natural products of plants may be a promising and underappreciated reservoir to circumvent the existing antibiotic resistance.

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References

65

[1]

Antibacterial drug discovery in the resistance era

Eric D. Brown, Gerard D. Wright

Nature 10.1038/nature17042

[2]

10.1126/science.352.6287.758

[3]

10.1086/595011

[4]

10.1016/s1473-3099(10)70258-9

[5]

10.1016/s1473-3099(15)00424-7

[6]

Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling

Elizabeth J. Culp, Nicholas Waglechner, Wenliang Wang et al.

Nature 10.1038/s41586-020-1990-9

[7]

10.1126/science.aax9176

[8]

10.1038/s41564-020-0723-z

[9]

10.1016/j.cell.2015.11.031

[10]

10.1039/c8np00031j

[11]

10.1038/nrd4510

[12]

10.1021/acs.jafc.9b01795

[13]

The Science of Antibiotic Discovery

Kim Lewis

Cell 10.1016/j.cell.2020.02.056

[14]

A new antibiotic kills pathogens without detectable resistance

Losee L. Ling, Tanja Schneider, Aaron J. Peoples et al.

Nature 10.1038/nature14098

[15]

10.1002/anie.201609277

[16]

Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens

Bradley M. Hover, Seong-Hwan Kim, Micah Katz et al.

Nature Microbiology 10.1038/s41564-018-0110-1

[17]

10.1016/j.cell.2019.04.016

[18]

A Deep Learning Approach to Antibiotic Discovery

Jonathan M. Stokes, Kevin Yang, Kyle Swanson et al.

Cell 10.1016/j.cell.2020.01.021

[19]

10.1002/advs.201902227

[20]

10.1038/nature18634

[21]

Discovery of MRSA active antibiotics using primary sequence from the human microbiome

John Chu, Xavier Vila-Farres, Daigo Inoyama et al.

Nature Methods 10.1038/nchembio.2207

[22]

A new antibiotic selectively kills Gram-negative pathogens

Yu Imai, Kirsten J. Meyer, Akira Iinishi et al.

Nature 10.1038/s41586-019-1791-1

[23]

10.1038/s41467-017-00419-5

[24]

10.1038/s41586-020-03074-x

[25]

The biomass distribution on Earth

Yinon M. Bar-On, Rob Phillips, Ron Milo

Proceedings of the National Academy of Sciences 10.1073/pnas.1711842115

[26]

10.1038/s41467-019-08555-w

[27]

10.1016/j.molmed.2007.04.004

[28]

10.1517/13543784.14.7.871

[29]

10.1089/jmf.2005.8.454

[30]

10.1007/978-1-4684-8511-0

[31]

10.1021/acs.chemrev.0c00922

[32]

10.1039/c1np00044f

[33]

10.1002/anie.200685399

[34]

10.1021/acs.jnatprod.8b00321

[35]

Chemistry and Biological Activities of Flavonoids: An Overview

Sahendara Kumar, Abhay K. Pandey

The Scientific World JOURNAL 10.1155/2013/162750

[36]

Phytocompounds modulating Aquaporins: Clinical benefits are anticipated

Piero Portincasa, Giuseppe Calamita

Food Chemistry 10.1016/j.foodchem.2018.09.029

[37]

10.1111/jam.14271

[38]

10.3390/plants5020027

[39]

10.3389/fmicb.2019.02489

[40]

10.1016/j.bmc.2019.115151

[41]

10.2174/092986709789057662

[42]

10.1038/nchembio.2263

[43]

10.1016/j.cell.2020.05.005

[44]

10.1038/nature26157

[45]

Clinical and Laboratory Standards Institute (CLSI) (2021)

[46]

10.4103/0973-7847.79095

[47]

Shen Y. B. mBio (2018)

[48]

10.1038/nmicrobiol.2017.28

[49]

10.1073/pnas.1611594113

[50]

10.4049/jimmunol.132.5.2582

Showing 50 of 65 references

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Metrics

341

Citations

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References

Details

Published: May 26, 2021
Vol/Issue: 8(15)
License: View

Authors

M

Meirong Song

National Center for Veterinary Drug Safety Evaluation College of Veterinary Medicine China Agricultural University Beijing 100193 China

Y

Ying Liu

National Center for Veterinary Drug Safety Evaluation College of Veterinary Medicine China Agricultural University Beijing 100193 China

T

Tingting Li

National Center for Veterinary Drug Safety Evaluation College of Veterinary Medicine China Agricultural University Beijing 100193 China

X

Xiaojia Liu

National Center for Veterinary Drug Safety Evaluation College of Veterinary Medicine China Agricultural University Beijing 100193 China

Z

Zhihui Hao

Center of Research and Innovation of Chinese Traditional Veterinary Medicine China Agricultural University Beijing 100193 China

S

Shuangyang Ding

Beijing Key Laboratory of Detection Technology for Animal‐Derived Food Safety and Beijing Laboratory for Food Quality and Safety China Agricultural University Beijing 100193 China

P

Pharkphoom Panichayupakaranant

Department of Pharmacognosy and Pharmaceutical Botany Faculty of Pharmaceutical Sciences Prince of Songkla University Hat‐Yai 90112 Thailand

K

Kui Zhu

National Center for Veterinary Drug Safety Evaluation College of Veterinary Medicine China Agricultural University Beijing 100193 China; Center of Research and Innovation of Chinese Traditional Veterinary Medicine China Agricultural University Beijing 100193 China

J

Jianzhong Shen

National Center for Veterinary Drug Safety Evaluation College of Veterinary Medicine China Agricultural University Beijing 100193 China; Beijing Key Laboratory of Detection Technology for Animal‐Derived Food Safety and Beijing Laboratory for Food Quality and Safety China Agricultural University Beijing 100193 China

Funding

National Natural Science Foundation of China Award: 31922083

China Postdoctoral Science Foundation Award: BX20200370

National Key Research and Development Program of China Award: 2017YFC1600305

Cite This Article

Meirong Song, Ying Liu, Tingting Li, et al. (2021). Plant Natural Flavonoids Against Multidrug Resistant Pathogens. Advanced Science, 8(15). https://doi.org/10.1002/advs.202100749

Plant Natural Flavonoids Against Multidrug Resistant Pathogens

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