Target Functionalized Carbon Dot Nanozymes with Dual‐Model Photoacoustic and Fluorescence Imaging for Visual Therapy in Atherosclerosis

AbstractMultifunctional nanomedicines have been used in atherosclerosis theranostics. Herein, phosphatidylserine‐specific peptide CLIKKPF‐functionalized carbon‐dots nanozymes (pep‐CDs) are reported for specific and efficient noninvasive theranostic of atherosclerosis. Surprisingly, pep‐CDs are discovered to not only inherit the inherent properties of carbon dots (CDs), including deep‐red fluorescence emission, photoacoustic response, and superoxide dismutase‐like antioxidant, and anti‐inflammatory activities but also possess the ability to target recognition on foam cells and target localization on plaques due to the specific interaction of CLIKKPF with phosphatidylserine on the membrane outer surface of foam cells. Furthermore, the target localization effect of pep‐CDs vastly promotes the efficient accumulation of CDs in plaque, thus maximizing AS theranostic of CDs. Interestingly, pep‐CDs could be developed to image plaque for monitoring atherosclerosis pathological progression in real‐time resulting from the different content of foam cells. This work on the one hand proposes a simple and feasible strategy to construct theranostic nanoplatform employing only a single functional unit (i.e., multifunctional CDs) to simplify the fabrication procedure, on the other hand, highlights the advantages of the active target auxiliary mode for atherosclerosis theranostic applications.

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Details

Published: Dec 25, 2023
Vol/Issue: 11(6)
License: View

Authors

Q

Qiao Chen

Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants Bioengineering College of Chongqing University Chongqing 400044 China

X

Xinmei Duan

Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants Bioengineering College of Chongqing University Chongqing 400044 China

Y

Yao Yu

Thyroid Breast Surgery Department Dazhou Central Hospital Dazhou 635000 China

R

Rongrong NI

Medical Department Southwest Hospital Third Military Medical University Chongqing 400038 China

G

Guojing Song

Urology Southwest Hospital Third Military Medical University Chongqing 400038 China

X

Xu Yang

Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants Bioengineering College of Chongqing University Chongqing 400044 China

L

Li Zhu

Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants Bioengineering College of Chongqing University Chongqing 400044 China

Y

Yuan Zhong

Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants Bioengineering College of Chongqing University Chongqing 400044 China

K

Kun Zhang

Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants Bioengineering College of Chongqing University Chongqing 400044 China; Chongqing University Three Gorges Hospital Chongqing 404000 China

K

Kai Qu

Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants Bioengineering College of Chongqing University Chongqing 400044 China; Chongqing University Three Gorges Hospital Chongqing 404000 China

X

Xian Qin

Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants Bioengineering College of Chongqing University Chongqing 400044 China; Chongqing University Three Gorges Hospital Chongqing 404000 China

W

Wei Wu

Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants Bioengineering College of Chongqing University Chongqing 400044 China; Jin Feng Laboratory Chongqing 401329 China

Funding

National Natural Science Foundation of China Award: 31971301

Natural Science Foundation of Chongqing Award: cstc2021jcyj‐msxmX0149

postdoctoral research foundation of china Award: 2022M710526

Cite This Article

Qiao Chen, Xinmei Duan, Yao Yu, et al. (2023). Target Functionalized Carbon Dot Nanozymes with Dual‐Model Photoacoustic and Fluorescence Imaging for Visual Therapy in Atherosclerosis. Advanced Science, 11(6). https://doi.org/10.1002/advs.202307441

Target Functionalized Carbon Dot Nanozymes with Dual‐Model Photoacoustic and Fluorescence Imaging for Visual Therapy in Atherosclerosis

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