Nanowire Array Breath Acetone Sensor for Diabetes Monitoring

Shiyu Wei; Zhe Li; Krishnan Murugappan; Ziyuan Li; Mykhaylo Lysevych; Kaushal Vora; Hark Hoe Tan; Chennupati Jagadish; Buddini I Karawdeniya; Christopher J Nolan; Antonio Tricoli; Lan Fu

doi:10.1002/advs.202309481

journal article Open Access Mar 13, 2024

Nanowire Array Breath Acetone Sensor for Diabetes Monitoring

Shiyu Wei Zhe Li

Krishnan Murugappan Ziyuan Li

Mykhaylo Lysevych Kaushal Vora Hark Hoe Tan

Chennupati Jagadish Buddini I Karawdeniya Christopher J Nolan Antonio Tricoli

Lan Fu

Advanced Science Vol. 11 No. 19 · Wiley

View at Publisher Save 10.1002/advs.202309481

Abstract

AbstractDiabetic ketoacidosis (DKA) is a life‐threatening acute complication of diabetes characterized by the accumulation of ketone bodies in the blood. Breath acetone, a ketone, directly correlates with blood ketones. Therefore, monitoring breath acetone can significantly enhance the safety and efficacy of diabetes care. In this work, the design and fabrication of an InP/Pt/chitosan nanowire array‐based chemiresistive acetone sensor is reported. By incorporation of chitosan as a surface‐functional layer and a Pt Schottky contact for efficient charge transfer processes and photovoltaic effect, self‐powered, highly selective acetone sensing is achieved. The sensor has exhibited an ultra‐wide acetone detection range from sub‐ppb to >100 000 ppm level at room temperature, covering those in the exhaled breath from healthy individuals (300–800 ppb) to people at high risk of DKA (>75 ppm). The nanowire sensor has also been successfully integrated into a handheld breath testing prototype, the Ketowhistle, which can successfully detect different ranges of acetone concentrations in simulated breath samples. The Ketowhistle demonstrates the immediate potential for non‐invasive ketone monitoring for people living with diabetes, in particular for DKA prevention.

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References

Details

Published: Mar 13, 2024
Vol/Issue: 11(19)
License: View

Authors

S

Shiyu Wei

Australian Research Council Centre of Excellence for Transformative Meta‐Optical Systems Department of Electronic Materials Engineering Research School of Physics The Australian National University Canberra ACT 2600 Australia

Z

Zhe Li

Australian Research Council Centre of Excellence for Transformative Meta‐Optical Systems Department of Electronic Materials Engineering Research School of Physics The Australian National University Canberra ACT 2600 Australia

K

Krishnan Murugappan

Commonwealth Scientific and Industrial Research Organisation (CSIRO) Mineral Resources Private Bag 10 Clayton South VIC 3169 Australia; Nanotechnology Research Laboratory Research School of Chemistry College of Science The Australian National University Canberra ACT 2600 Australia

Z

Ziyuan Li

Australian Research Council Centre of Excellence for Transformative Meta‐Optical Systems Department of Electronic Materials Engineering Research School of Physics The Australian National University Canberra ACT 2600 Australia

M

Mykhaylo Lysevych

Australian National Fabrication Facility The Australian National University Canberra ACT 2600 Australia

K

Kaushal Vora

Australian National Fabrication Facility The Australian National University Canberra ACT 2600 Australia

H

Hark Hoe Tan

Australian Research Council Centre of Excellence for Transformative Meta‐Optical Systems Department of Electronic Materials Engineering Research School of Physics The Australian National University Canberra ACT 2600 Australia

C

Chennupati Jagadish

Australian Research Council Centre of Excellence for Transformative Meta‐Optical Systems Department of Electronic Materials Engineering Research School of Physics The Australian National University Canberra ACT 2600 Australia

B

Buddini I Karawdeniya

Australian Research Council Centre of Excellence for Transformative Meta‐Optical Systems Department of Electronic Materials Engineering Research School of Physics The Australian National University Canberra ACT 2600 Australia

C

Christopher J Nolan

School of Medicine and Psychology College of Health and Medicine The Australian National University Canberra ACT 2600 Australia; Department of Diabetes and Endocrinology The Canberra Hospital Garran ACT 2605 Australia

A

Antonio Tricoli

Nanotechnology Research Laboratory Research School of Chemistry College of Science The Australian National University Canberra ACT 2600 Australia; Nanotechnology Research Laboratory Faculty of Engineering The University of Sydney Camperdown 2006 Australia

L

Lan Fu

Australian Research Council Centre of Excellence for Transformative Meta‐Optical Systems Department of Electronic Materials Engineering Research School of Physics The Australian National University Canberra ACT 2600 Australia

Funding

Australian Research Council Award: FutureFellowshipgrant(FT200100939)

China Scholarship Council

Cite This Article

Shiyu Wei, Zhe Li, Krishnan Murugappan, et al. (2024). Nanowire Array Breath Acetone Sensor for Diabetes Monitoring. Advanced Science, 11(19). https://doi.org/10.1002/advs.202309481

Nanowire Array Breath Acetone Sensor for Diabetes Monitoring

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