Ultrasound‐Responsive HBD Peptide Hydrogel with Antibiofilm Capability for Fast Diabetic Wound Healing

Lanlan Zong; Runxin Teng; Huiqi Zhang; Wenshang Liu; Yu Feng; Zhicheng Lu; Yuxiao Zhou; Zhen Fan; Meng Li; Xiaohui Pu

doi:10.1002/advs.202406022

journal article Open Access Sep 09, 2024

Ultrasound‐Responsive HBD Peptide Hydrogel with Antibiofilm Capability for Fast Diabetic Wound Healing

Lanlan Zong Runxin Teng Huiqi Zhang Wenshang Liu Yu Feng

Zhicheng Lu Yuxiao Zhou

Zhen Fan

Meng Li

Xiaohui Pu

Advanced Science Vol. 11 No. 42 · Wiley

View at Publisher Save 10.1002/advs.202406022

Abstract

AbstractDespite advancements in therapeutic agents for diabetic chronic wounds, challenges such as suboptimal bioavailability, intricate disease milieus, and inadequate delivery efficacy have impeded treatment outcomes. Here, ultrasound‐responsive hydrogel incorporated with heparin‐binding domain (HBD) peptide nanoparticles is developed to promote diabetic wound healing. HBD peptide, derived from von Willebrand Factor with angiogenic activity, are first engineered to self‐assemble into nanoparticles with enhanced biostability and bioavailability. Ultrasound responsive cargo release and hydrogel collapses are first verified through breakage of crosslinking. In addition, desired antioxidant and antibacterial activity of such hydrogel is observed. Moreover, the degradation of hydrogel under ultrasound stimulation into smaller fragments facilitated the deeper wound penetration of ≈400 µm depth. Complete wound closure is observed from diabetic mice with chronic wounds after being treated with the proposed hydrogel. In detail, in vivo studies revealed that hydrogels loaded with HBD peptide nanoparticles increased the levels of angiogenesis‐related growth factors (VEGF‐A, CD31, and α‐SMA) to effectively accelerate wound repair. Overall, this study demonstrates that ultrasound‐responsive HBD peptide hydrogel provides a synergistic therapeutic strategy for external biofilm elimination and internal effective delivery for diabetic wounds with biofilm infection.

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References

42

[1]

Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021

Kanyin Liane Ong, Lauryn K Stafford, Susan A McLaughlin et al.

The Lancet 10.1016/s0140-6736(23)01301-6

[2]

10.1039/d0bm01747g

[3]

10.3390/ijms18071419

[4]

10.3390/medicina57101072

[5]

10.1021/acs.accounts.0c00864

[6]

10.1016/j.actbio.2022.08.048

[7]

10.1016/j.carbpol.2023.120823

[8]

10.3389/fcimb.2020.538077

[9]

10.1007/s00253-020-10349-w

[10]

10.1016/j.biomaterials.2020.119936

[11]

Antibacterial drug discovery in the resistance era

Eric D. Brown, Gerard D. Wright

Nature 10.1038/nature17042

[12]

Abu‐Ashour W. Infect. Dis. (2018)

[13]

10.1016/j.isprsjprs.2017.02.003

[14]

10.1021/acsnano.9b02845

[15]

10.3390/polym12092168

[16]

10.1021/acsnano.2c01407

[17]

Cai Y. Biomed Res. Int. (2017)

[18]

10.1016/j.carbpol.2023.121655

[19]

10.1016/j.compositesb.2021.109390

[20]

10.1016/j.ultsonch.2023.106687

[21]

10.1016/j.ijbiomac.2023.125650

[22]

10.1016/j.carbpol.2018.01.025

[23]

10.1016/j.compositesb.2022.110096

[24]

10.1002/adfm.202213729

[25]

Xu Q. Natl. Sci. Rev. (2023)

[26]

10.1016/j.cej.2023.143985

[27]

Therapeutic strategies for enhancing angiogenesis in wound healing

Austin P. Veith, Kayla Henderson, Adrianne Spencer et al.

Advanced Drug Delivery Reviews 10.1016/j.addr.2018.09.010

[28]

10.1126/science.aar3318

[29]

10.1038/srep23021

[30]

10.1182/blood.2019000510

[31]

10.1016/j.cej.2020.124728

[32]

10.1126/sciadv.adf8645

[33]

10.1016/j.biomaterials.2020.120614

[34]

10.1161/01.cir.0000091257.27563.32

[35]

10.1155/2019/9316380

[36]

10.1186/s40729-021-00314-1

[37]

10.1021/acs.nanolett.9b04290

[38]

10.1038/s41467-023-43067-8

[39]

10.1002/adhm.201500005

[40]

10.1002/smll.202106172

[41]

10.1016/j.biomaterials.2018.08.044

[42]

10.1016/j.ijbiomac.2022.06.210

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Details

Published: Sep 09, 2024
Vol/Issue: 11(42)
License: View

Authors

L

Lanlan Zong

State Key Laboratory of Antiviral Drugs Henan Province Engineering Research Center of High Value Utilization to Natural Medical Resource in Yellow River Basin School of Pharmacy Henan University N. Jinming Ave. Kaifeng 475004 P. R. China

R

Runxin Teng

Department of Polymeric Materials School of Materials Science and Engineering Tongji University 4800 Caoan Road Shanghai 201804 P. R. China

H

Huiqi Zhang

State Key Laboratory of Antiviral Drugs Henan Province Engineering Research Center of High Value Utilization to Natural Medical Resource in Yellow River Basin School of Pharmacy Henan University N. Jinming Ave. Kaifeng 475004 P. R. China

W

Wenshang Liu

State Key Laboratory of Antiviral Drugs Henan Province Engineering Research Center of High Value Utilization to Natural Medical Resource in Yellow River Basin School of Pharmacy Henan University N. Jinming Ave. Kaifeng 475004 P. R. China; Department of Dermatology Shanghai Children's Medical Center Shanghai Jiaotong University School of Medicine Shanghai 200127 P. R. China

Y

Yu Feng

State Key Laboratory of Antiviral Drugs Henan Province Engineering Research Center of High Value Utilization to Natural Medical Resource in Yellow River Basin School of Pharmacy Henan University N. Jinming Ave. Kaifeng 475004 P. R. China

Z

Zhicheng Lu

Department of Gastrointestinal Surgery The First Affiliated Hospital of Naval Medical University Shanghai 200433 P. R. China

Y

Yuxiao Zhou

Department of Gynaecology and Obstetrics, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain‐Like Intelligence Shanghai Fourth People's Hospital, School of Medicine Tongji University Shanghai 200434 P. R. China

Z

Zhen Fan

Department of Polymeric Materials School of Materials Science and Engineering Tongji University 4800 Caoan Road Shanghai 201804 P. R. China; Department of Gynaecology and Obstetrics, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain‐Like Intelligence Shanghai Fourth People's Hospital, School of Medicine Tongji University Shanghai 200434 P. R. China

M

Meng Li

Department of Dermatology Shanghai Children's Medical Center Shanghai Jiaotong University School of Medicine Shanghai 200127 P. R. China

X

Xiaohui Pu

State Key Laboratory of Antiviral Drugs Henan Province Engineering Research Center of High Value Utilization to Natural Medical Resource in Yellow River Basin School of Pharmacy Henan University N. Jinming Ave. Kaifeng 475004 P. R. China

Funding

National Natural Science Foundation of China Award: 22075212

Cite This Article

Lanlan Zong, Runxin Teng, Huiqi Zhang, et al. (2024). Ultrasound‐Responsive HBD Peptide Hydrogel with Antibiofilm Capability for Fast Diabetic Wound Healing. Advanced Science, 11(42). https://doi.org/10.1002/advs.202406022

Ultrasound‐Responsive HBD Peptide Hydrogel with Antibiofilm Capability for Fast Diabetic Wound Healing

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