Emerging Biosensor Technologies for Stroke Biomarker Detection: A Comprehensive Overview

Ghazal Koohkansaadi; Arash Mohagheghi; Ahmad Mobed; Saeid Charsouei

doi:10.1002/ansa.70035

journal article Open Access Aug 12, 2025

Emerging Biosensor Technologies for Stroke Biomarker Detection: A Comprehensive Overview

Ghazal Koohkansaadi Arash Mohagheghi Ahmad Mobed Saeid Charsouei

Analytical Science Advances Vol. 6 No. 2 · Wiley

View at Publisher Save 10.1002/ansa.70035

Abstract

ABSTRACT
Stroke remains a leading cause of morbidity and mortality worldwide, necessitating the development of rapid and reliable diagnostic tools for early detection and management. This manuscript presents an overview of innovative biosensors designed for the detection of key stroke biomarkers, including N‐terminal pro B‐type natriuretic peptide (NT‐proBNP), C‐reactive protein (CRP), D‐dimer, cardiac troponins, S100B protein, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), matrix metalloproteinases (MMPs), interleukins and fibrinogen. We discuss the principles of operation, sensitivity, specificity and the technological advancements that have enabled the development of these biosensors, including electrochemical, optical and microfluidic platforms. The integration of nanomaterials and advanced signal amplification techniques has significantly enhanced the performance of these biosensors, allowing for the detection of biomarkers at low concentrations in complex biological samples. Furthermore, we explore the clinical implications of these biosensors in the context of stroke diagnosis, prognosis and monitoring, highlighting their potential to facilitate timely therapeutic interventions. By providing a comprehensive discussion on the current state of biosensor technology for stroke biomarker detection, this manuscript aims to underscore the importance of these tools in improving patient outcomes and advancing stroke research. Future directions for biosensor development and the challenges that remain in translating these technologies into clinical practice are also addressed.

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Metrics

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Citations

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References

Details

Published: Aug 12, 2025
Vol/Issue: 6(2)
License: View

Authors

G

Ghazal Koohkansaadi

Department of Psychology University of New Hampshire Durham New Hampshire USA

A

Arash Mohagheghi

Research Center of Psychiatry and Behavioral Sciences Tabriz University of Medical Sciences Tabriz Iran

A

Ahmad Mobed

Social Determinants of Health Research Center Health Management and Safety Promotion Tabriz Iran

S

Saeid Charsouei

Department of Neurology Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran

Cite This Article

Ghazal Koohkansaadi, Arash Mohagheghi, Ahmad Mobed, et al. (2025). Emerging Biosensor Technologies for Stroke Biomarker Detection: A Comprehensive Overview. Analytical Science Advances, 6(2). https://doi.org/10.1002/ansa.70035

Emerging Biosensor Technologies for Stroke Biomarker Detection: A Comprehensive Overview

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