Synthesis, characterization and cytotoxicity of platinum(II) complexes containing reduced amino acid ester Schiff bases

Qin‐Qin Yan; Zhen Yuan; Guo‐Jun Liu; Zheng‐Hua Lv; Bin Fu; Jian‐Long Du; Li‐Jun Li

doi:10.1002/aoc.3689

journal article Dec 13, 2016

Synthesis, characterization and cytotoxicity of platinum(II) complexes containing reduced amino acid ester Schiff bases

Qin‐Qin Yan Zhen Yuan

Guo‐Jun Liu Zheng‐Hua Lv Bin Fu

Jian‐Long Du Li‐Jun Li

Applied Organometallic Chemistry Vol. 31 No. 6 · Wiley

View at Publisher Save 10.1002/aoc.3689

Abstract

Nine platinum(II) complexes containing reduced amino acid ester Schiff bases were synthesized and characterized using spectroscopy (1H NMR, 13C NMR, infrared), elemental analysis and molar conductivity. The interaction of these complexes with salmon sperm DNA was investigated by means of ultraviolet and circular dichroism spectroscopies. The potential antitumor activity of all compounds was tested in vitro on HeLa and A549 tumor cell lines. Almost all the complexes exhibited better cytotoxic activity than cisplatin against these cell lines.

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Published: Dec 13, 2016
Vol/Issue: 31(6)
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Authors

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Qin‐Qin Yan