Modulating the burst drug release effect of waterborne polyurethane matrix by modifying with polymethylmethacrylate

A. Bahadur; A. Saeed; M. Shoaib; S. Iqbal; S. Anwer

doi:10.1002/app.47253

journal article Nov 18, 2018

Modulating the burst drug release effect of waterborne polyurethane matrix by modifying with polymethylmethacrylate

A. Bahadur A. Saeed M. Shoaib

S. Iqbal S. Anwer

Journal of Applied Polymer Science Vol. 136 No. 13 · Wiley

View at Publisher Save 10.1002/app.47253

Abstract

ABSTRACTTo reduce cost and increase environmental friendliness, waterborne polyurethane (WPU) is a tempting choice in the field of green chemistry. Biodegradable WPU was synthesized using lysine as an internal emulsifier. WPU was further modified using methylate methacrylate (MMA) as an acrylic monomer. Unsaturated pre‐PU was synthesized by using unsaturated end‐capping agent 2‐hydroxyethyl methacrylate and further extended by MMA to form acrylate modified WPU. A permanent covalent linkage was established between WPU and PMMA as confirmed by FTIR spectroscopy. The focus of this research work was to study the dependence of drug delivery, mechanical, thermal, surface, and structural properties of WPU, on the MMA repeating unit content (10%–40%). For drug release studies mitomycin c was taken as a model anticancer drug. Furthermore, these materials were subjected to in vitro and in vivo cytotoxicity evaluation, which shows that synthesized acrylate modified WPU are biocompatible. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47253.

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Metrics

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Citations

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References

Details

Published: Nov 18, 2018
Vol/Issue: 136(13)
License: View

Authors

A

A. Bahadur

Department of Chemistry Quaid‐i‐Azam University Islamabad 45320 Pakistan

A

A. Saeed

Department of Chemistry Quaid‐i‐Azam University Islamabad 45320 Pakistan

M

M. Shoaib

Department of Chemistry Quaid‐i‐Azam University Islamabad 45320 Pakistan

S

S. Iqbal

School of Chemistry and Chemical Engineering University of Chinese Academy of Sciences Beijing 100049 P.R. China

S

S. Anwer

Department of Mechanical Engineering Khalifa University P. O. Box: 127788, Abu Dhabi United Arab Emirates

Funding

National Natural Science Foundation of China Award: 51850410508

China Postdoctoral Science Foundation Award: 2018M633502

Quaid-i-Azam University

Cite This Article

A. Bahadur, A. Saeed, M. Shoaib, et al. (2018). Modulating the burst drug release effect of waterborne polyurethane matrix by modifying with polymethylmethacrylate. Journal of Applied Polymer Science, 136(13). https://doi.org/10.1002/app.47253

Modulating the burst drug release effect of waterborne polyurethane matrix by modifying with polymethylmethacrylate

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