Effect of network mesh size and swelling to the drug delivery from pH responsive hydrogels

Rachel A. Hegab; Sibile Pardue; Xinggui Shen; Christopher Kevil; Nicholas A. Peppas; Mary E. Caldorera‐Moore

doi:10.1002/app.48767

journal article Dec 04, 2019

Effect of network mesh size and swelling to the drug delivery from pH responsive hydrogels

Rachel A. Hegab Sibile Pardue Xinggui Shen

Christopher Kevil Nicholas A. Peppas

Mary E. Caldorera‐Moore

Journal of Applied Polymer Science Vol. 137 No. 25 · Wiley

View at Publisher Save 10.1002/app.48767

Abstract

ABSTRACTpH responsive hydrogels are ideal platforms for numerous therapeutic delivery applications, including oral delivery, as they are capable of overcoming the many barriers that must be considered when creating an effective drug delivery system. Understanding of the innate hydrogel network structure and its swelling behavior at environmentally relevant conditions is vital for designing hydrogel network capable of effective controlled drug release. Herein, we explored how to expand traditional techniques of swelling and pore characterization to gain better insight into the performance of anionic microparticles composed of the poly(methyl methacrylate‐co‐acrylic acid) with varying molar percentage of 10, 20, and 30 mol% of MMA, for controlled release of low‐molecular‐weight drugs. By evaluating these carrier systems at environmental conditions, we can observe changes in swelling and pore size of the anionic hydrogel networks as a function of MMA, which was then correlated with the release profiles of the small‐molecular‐weight drug sodium nitrate. With the correlation of the swelling behavior of the networks and the release profiles, we demonstrated how the expansion of swelling parameters at relevant pH values provides further incite for evaluating for the optimal blend for controlled release. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48767.

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Metrics

25

Citations

36

References

Details

Published: Dec 04, 2019
Vol/Issue: 137(25)
License: View

Authors

R

Rachel A. Hegab

Department of Biomedical Engineering Louisiana Tech University Ruston Louisiana 71272

S

Sibile Pardue

Center for Cardiovascular Diseases and Sciences LSU Health Shreveport Shreveport Louisiana 71130‐3932

X

Xinggui Shen

Center for Cardiovascular Diseases and Sciences LSU Health Shreveport Shreveport Louisiana 71130‐3932

C

Christopher Kevil

Center for Cardiovascular Diseases and Sciences LSU Health Shreveport Shreveport Louisiana 71130‐3932

N

Nicholas A. Peppas

McKetta Department of Chemical Engineering The University of Texas at Austin Austin Texas 78712; Department of Biomedical Engineering The University of Texas at Austin Austin Texas 78712; Institute for Biomaterials, Drug Delivery, and Regenerative Medicine The University of Texas at Austin Austin Texas 78712; Department of Surgery and Perioperative Care, Dell Medical School The University of Texas at Austin Austin Texas 78712; Department of Pediatrics, Dell Medical School The University of Texas at Austin Austin Texas 78712

M

Mary E. Caldorera‐Moore

Department of Biomedical Engineering Louisiana Tech University Ruston Louisiana 71272

Funding

Louisiana Board of Regents Award: LEQSF(2015‐18)‐RD‐A‐17

Cite This Article

Rachel A. Hegab, Sibile Pardue, Xinggui Shen, et al. (2019). Effect of network mesh size and swelling to the drug delivery from pH responsive hydrogels. Journal of Applied Polymer Science, 137(25). https://doi.org/10.1002/app.48767

Effect of network mesh size and swelling to the drug delivery from pH responsive hydrogels

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