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journal article Apr 24, 2007

High fever–related maternal diseases as possible causes of multiple congenital abnormalities: A population‐based case‐control study

Andrew E. Czeizel Erzsébet H. Puhó Nándor Ács Ferenc Bánhidy ORCID
Birth Defects Research Part A: Clinical and Molecular Teratology Vol. 79 No. 7 pp. 544-551 · Wiley
View at Publisher Save 10.1002/bdra.20369
Abstract
AbstractBACKGROUND:Multiple congenital abnormalities (MCAs) represent the most severe category of structural birth defects; therefore, we decided to evaluate the possible etiological factors for MCAs.METHODS:The population‐based large data set of the Hungarian Case‐Control Surveillance of Congenital Abnormalities (1980–1996) was evaluated.RESULTS:We compared the data of 1,349 cases with MCAs, 2,405 matched population controls without any defect, and 21,494 malformed controls with isolated congenital abnormalities. An association was found between a higher risk for MCAs and high fever–related influenza, common cold with secondary complications, tonsillitis, and recurrent orofacial herpes (adjusted ORs with 95% CIs: 2.3, 1.8–2.9). However, the risk for MCAs was reduced by antifever drug therapy (adjusted OR with 95% CI: 1.6, 0.9–2.9).CONCLUSIONS:An association was found between high fever–related maternal diseases and a higher risk for MCAs; however, a certain portion of these MCAs is preventable by antifever therapy. Birth Defects Research (Part A) 2007. © 2007 Wiley‐Liss, Inc.
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Metrics
31
Citations
47
References
Details
Published
Apr 24, 2007
Vol/Issue
79(7)
Pages
544-551
License
View
Authors
A
Andrew E. Czeizel
E
Erzsébet H. Puhó
N
Nándor Ács
F
Ferenc Bánhidy

Second Department of Obstetrics and Gynecology, School of Medicine, Semmelweis University, Ulloi ut 78/a, Budapest 1082, Hungary

Cite This Article
Andrew E. Czeizel, Erzsébet H. Puhó, Nándor Ács, et al. (2007). High fever–related maternal diseases as possible causes of multiple congenital abnormalities: A population‐based case‐control study. Birth Defects Research Part A: Clinical and Molecular Teratology, 79(7), 544-551. https://doi.org/10.1002/bdra.20369
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