TGFβ signaling in cartilage development and maintenance

Weiguang Wang; Diana Rigueur; Karen M. Lyons

doi:10.1002/bdrc.21058

journal article Mar 01, 2014

TGFβ signaling in cartilage development and maintenance

Weiguang Wang

Diana Rigueur Karen M. Lyons

Birth Defects Research Part C: Embryo Today: Reviews Vol. 102 No. 1 pp. 37-51 · Wiley

View at Publisher Save 10.1002/bdrc.21058

Abstract

Members of the transforming growth factor beta (TGFβ) superfamily of secreted factors play essential roles in nearly every aspect of cartilage formation and maintenance. However, the mechanisms by which TGFβs transduce their effects in cartilage in vivo remain poorly understood. Mutations in several TGFβ family members, their receptors, extracellular modulators, and intracellular transducers have been described, and these usually impact the development of the cartilaginous skeleton. Furthermore, genome‐wide association studies have linked components of the (TGFβ) superfamily to susceptibility to osteoarthritis. This review focuses on recent discoveries from genetic studies in the mouse regarding the regulation of TGFβ signaling in developing growth plate and articular cartilage, as well as the different modes of crosstalk between canonical and noncanonical TGFβ signaling. These new insights into TGFβ signaling in cartilage may open new prospects for therapies that maintain healthy articular cartilage. Birth Defects Research (Part C) 102:37–51, 2014. © 2014 Wiley Periodicals, Inc.

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Details

Published: Mar 01, 2014
Vol/Issue: 102(1)
Pages: 37-51
License: View

Authors

W

Weiguang Wang

Department of Orthopaedic Surgery and Orthopaedic Institute for Children, David Geffen School of Medicine University of California Los Angeles California 90095

D

Diana Rigueur

Department of Orthopaedic Surgery and Orthopaedic Institute for Children, David Geffen School of Medicine University of California Los Angeles California 90095; Department of Molecular, Cell and Developmental Biology David Geffen School of Medicine University of California Los Angeles California 90095

K

Karen M. Lyons

Department of Orthopaedic Surgery and Orthopaedic Institute for Children, David Geffen School of Medicine University of California Los Angeles California 90095; Department of Molecular, Cell and Developmental Biology David Geffen School of Medicine University of California Los Angeles California 90095; Molecular Biology Institute, David Geffen School of Medicine University of California Los Angeles California 90095

Cite This Article

Weiguang Wang, Diana Rigueur, Karen M. Lyons (2014). TGFβ signaling in cartilage development and maintenance. Birth Defects Research Part C: Embryo Today: Reviews, 102(1), 37-51. https://doi.org/10.1002/bdrc.21058

TGFβ signaling in cartilage development and maintenance

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