hnRNP K: One protein multiple processes

Karol Bomsztyk; Oleg Denisenko; Jerzy Ostrowski

doi:10.1002/bies.20048

journal article May 24, 2004

hnRNP K: One protein multiple processes

Karol Bomsztyk Oleg Denisenko Jerzy Ostrowski

BioEssays Vol. 26 No. 6 pp. 629-638 · Wiley

View at Publisher Save 10.1002/bies.20048

Abstract

AbstractSince its original identification as a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, K protein has been found not only in the nucleus but also in the cytoplasm and mitochondria and is implicated in chromatin remodeling, transcription, splicing and translation processes. K protein contains multiple modules that, on one hand, bind kinases while, on the other hand, recruit chromatin, transcription, splicing and translation factors. Moreover, the K‐ protein‐mediated interactions are regulated by signaling cascades. These observations are consistent with K protein acting as a docking platform to integrate signaling cascades by facilitating cross‐talk between kinases and factors that mediate nucleic‐acid‐directed processes. Comparison of K across species reveals that it is an essential factor in metazoans, but not in yeast. Although some of the K protein interactions and functions are conserved in eukaryotes from yeast to man, the mammalian protein seems to play a wider role. The greater diversity of mammalian K protein interactions and function may reflect gain of novel docking sites and expansion evolutionary of gene expression networks. BioEssays 26:629–638, 2004. © 2004 Wiley Periodicals, Inc.

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Metrics

392

Citations

80

References

Details

Published: May 24, 2004
Vol/Issue: 26(6)
Pages: 629-638
License: View

Authors

Cite This Article

Karol Bomsztyk, Oleg Denisenko, Jerzy Ostrowski (2004). hnRNP K: One protein multiple processes. BioEssays, 26(6), 629-638. https://doi.org/10.1002/bies.20048

hnRNP K: One protein multiple processes

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