Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals

Anne K. Voss; Tim Thomas

doi:10.1002/bies.201800078

journal article Aug 24, 2018

Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals

Anne K. Voss Tim Thomas

BioEssays Vol. 40 No. 10 · Wiley

View at Publisher Save 10.1002/bies.201800078

Abstract

Histone acetylation has been recognized as an important post‐translational modification of core nucleosomal histones that changes access to the chromatin to allow gene transcription, DNA replication, and repair. Histone acetyltransferases were initially identified as co‐activators that link DNA‐binding transcription factors to the general transcriptional machinery. Over the years, more chromatin‐binding modes have been discovered suggesting direct interaction of histone acetyltransferases and their protein complex partners with histone proteins. While much progress has been made in characterizing histone acetyltransferase complexes biochemically, cell‐free activity assay results are often at odds with in‐cell histone acetyltransferase activities. In‐cell studies suggest specific histone lysine targets, but broad recruitment modes, apparently not relying on specific DNA sequences, but on chromatin of a specific functional state. Here we review the evidence for general versus specific roles of individual nuclear lysine acetyltransferases in light of in vivo and in vitro data in the mammalian system.

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Details

Published: Aug 24, 2018
Vol/Issue: 40(10)
License: View

Authors

A

Anne K. Voss

Walter and Eliza Hall Institute of Medical Research 3 1G Royal Parade, Parkville Melbourne Victoria 3052 Australia

T

Tim Thomas

Department of Medical Biology The University of Melbourne 1G Royal Parade, Parkville Melbourne Victoria 3052 Australia

Funding

National Health and Medical Research Council Award: 1081421

Cite This Article

Anne K. Voss, Tim Thomas (2018). Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals. BioEssays, 40(10). https://doi.org/10.1002/bies.201800078

Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals

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