Aggression modulator: Understanding the multifaceted role of the dorsal raphe nucleus

Koshiro Mitsui; Aki Takahashi

doi:10.1002/bies.202300213

journal article Feb 05, 2024

Aggression modulator: Understanding the multifaceted role of the dorsal raphe nucleus

Koshiro Mitsui Aki Takahashi

BioEssays Vol. 46 No. 4 · Wiley

View at Publisher Save 10.1002/bies.202300213

Abstract

AbstractAggressive behavior is instinctively driven behavior that helps animals to survive and reproduce and is closely related to multiple behavioral and physiological processes. The dorsal raphe nucleus (DRN) is an evolutionarily conserved midbrain structure that regulates aggressive behavior by integrating diverse brain inputs. The DRN consists predominantly of serotonergic (5‐HT:5‐hydroxytryptamine) neurons and decreased 5‐HT activity was classically thought to increase aggression. However, recent studies challenge this 5‐HT deficiency model, revealing a more complex role for the DRN 5‐HT system in aggression. Furthermore, emerging evidence has shown that non‐5‐HT populations in the DRN and specific neural circuits contribute to the escalation of aggressive behavior. This review argues that the DRN serves as a multifaceted modulator of aggression, acting not only via 5‐HT but also via other neurotransmitters and neural pathways, as well as different subsets of 5‐HT neurons. In addition, we discuss the contribution of DRN neurons in the behavioral and physiological aspects implicated in aggressive behavior, such as arousal, reward, and impulsivity, to further our understanding of DRN‐mediated aggression modulation.

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Metrics

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Citations

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References

Details

Published: Feb 05, 2024
Vol/Issue: 46(4)
License: View

Authors

K

Koshiro Mitsui

Laboratory of Behavioral Neurobiology University of Tsukuba Tsukuba Ibaraki Japan; Graduate School of Comprehensive Human Sciences University of Tsukuba Tsukuba Ibaraki Japan

A

Aki Takahashi

Laboratory of Behavioral Neurobiology University of Tsukuba Tsukuba Ibaraki Japan; Institute of Human Sciences University of Tsukuba Tsukuba Ibaraki Japan

Funding

Astellas Foundation for Research on Metabolic Disorders

Cite This Article

Koshiro Mitsui, Aki Takahashi (2024). Aggression modulator: Understanding the multifaceted role of the dorsal raphe nucleus. BioEssays, 46(4). https://doi.org/10.1002/bies.202300213

Aggression modulator: Understanding the multifaceted role of the dorsal raphe nucleus

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