Association between metformin prescription and growth rates of abdominal aortic aneurysms

J Golledge; J Moxon; J Pinchbeck; G Anderson; S Rowbotham; J Jenkins; M Bourke; B Bourke; A Dear; T Buckenham; P E Norman

doi:10.1002/bjs.10587

journal article Jun 26, 2017

Association between metformin prescription and growth rates of abdominal aortic aneurysms

J Golledge J Moxon J Pinchbeck G Anderson S Rowbotham J Jenkins M Bourke B Bourke A Dear T Buckenham P E Norman

British Journal of Surgery Vol. 104 No. 11 pp. 1486-1493 · Oxford University Press (OUP)

View at Publisher Save 10.1002/bjs.10587

Abstract

Abstract

Background
It has been suggested that diabetes medications, such as metformin, may have effects that inhibit abdominal aortic aneurysm (AAA) growth. The aim of this study was to examine the association of diabetes treatments with AAA growth in three patient cohorts.

Methods
AAA growth was studied using ultrasound surveillance in cohort 1, repeated CT in cohort 2 and more detailed repeat CT in cohort 3. Growth was estimated by the mean annual increase in maximum AAA diameter.

Results
A total of 1697 patients with an AAA were studied, of whom 118, 39 and 16 patients were prescribed metformin for the treatment of diabetes in cohorts 1, 2 and 3 respectively. Prescription of metformin was associated with a reduced likelihood of median or greater AAA growth in all three cohorts (cohort 1: adjusted odds ratio (OR) 0·59, 95 per cent c.i. 0·39 to 0·87, P = 0·008; cohort 2: adjusted OR 0·38, 0·18 to 0·80, P = 0·011; cohort 3: adjusted OR 0·13, 0·03 to 0·61, P = 0·010). No other diabetes treatment was significantly associated with AAA growth in any cohort.

Conclusion
These findings suggest a potential role for metformin in limiting AAA growth.

Topics

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Details

Published: Jun 26, 2017
Vol/Issue: 104(11)
Pages: 1486-1493
License: View

Authors

J

J Golledge

Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia; Department of Vascular and Endovascular Surgery, Townsville Hospital, Townsville, Queensland, Australia

J

J Moxon

Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia

J

J Pinchbeck

Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia

G

G Anderson

Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia

S

S Rowbotham

Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia; School of Medicine, University of Queensland, Brisbane, Queensland, Australia; Royal Brisbane and Women's Hospital, Herston, Queensland, Australia

J

J Jenkins

Royal Brisbane and Women's Hospital, Herston, Queensland, Australia

M

M Bourke

Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia; Gosford Vascular Clinic, Gosford, New South Wales, Australia

B

B Bourke

Gosford Vascular Clinic, Gosford, New South Wales, Australia

A

A Dear

Eastern Health Clinical School, Monash University and Department of Medicine, Box Hill Hospital, Melbourne, Victoria, Australia

T

T Buckenham

Christchurch School of Medicine and Health Sciences, Otago University, Christchurch, New Zealand

P

P E Norman

School of Surgery, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia

Funding

National Health and Medical Research Council Award: 1022752

Queensland Government

Cite This Article

J Golledge, J Moxon, J Pinchbeck, et al. (2017). Association between metformin prescription and growth rates of abdominal aortic aneurysms. British Journal of Surgery, 104(11), 1486-1493. https://doi.org/10.1002/bjs.10587

Association between metformin prescription and growth rates of abdominal aortic aneurysms

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