The neurological phenotype of developmental motor patterns during early childhood

Marieke J. Kuiper; Rick Brandsma; Roelineke J. Lunsing; Hendriekje Eggink; Hendrik J. ter Horst; Arend F. Bos; Deborah A. Sival

doi:10.1002/brb3.1153

journal article Open Access Nov 28, 2018

The neurological phenotype of developmental motor patterns during early childhood

Marieke J. Kuiper Rick Brandsma Roelineke J. Lunsing Hendriekje Eggink Hendrik J. ter Horst Arend F. Bos Deborah A. Sival

Brain and Behavior Vol. 9 No. 1 · Wiley

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Abstract

AbstractIntroductionDuring early childhood, typical human motor behavior reveals a gradual transition from automatic motor patterns to acquired motor skills, by the continuous interplay between nature and nurture. During the wiring and shaping of the underlying motor networks, insight into the neurological phenotype of developmental motor patterns is incomplete. In healthy, typically developing children (0–3 years of age), we therefore aimed to investigate the neurological phenotype of developmental motor patterns.MethodsIn 32 healthy, typically developing children (0–3 years), we video‐recorded spontaneous motor behavior, general movements (GMs), and standardized motor tasks. We classified the motor patterns by: (a) the traditional neurodevelopmental approach, by Gestalt perception and (b) the classical neurological approach, by the clinical phenotypic determination of movement disorder features. We associated outcomes by Cramer's V.ResultsDevelopmental motor patterns revealed (a) choreatic‐like features (≤3 months; associated with fidgety GMs (r = 0.732) and startles (r = 0.687)), (b) myoclonic‐like features (≤3 months; associated with fidgety GMs (r = 0.878) and startles (r = 0.808)), (c) dystonic‐like features (0–3 years; associated with asymmetrical tonic neck reflex (r = 0.641) and voluntary movements (r = 0.517)), and (d) ataxic‐like features (>3 months; associated with voluntary movements (r = 0.928)).ConclusionsIn healthy infants and toddlers (0–3 years), typical developmental motor patterns reveal choreatic‐, myoclonic‐, dystonic‐ and ataxic‐like features. The transient character of these neurological phenotypes is placed in perspective of the physiological shaping of the underlying motor centers. Neurological phenotypic insight into developmental motor patterns can contribute to adequate discrimination between ontogenetic and initiating pathological movement features and to adequate interpretation of therapeutic interactions.

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Details

Published: Nov 28, 2018
Vol/Issue: 9(1)
License: View

Authors

M

Marieke J. Kuiper

Department of Neurology University Medical Center Groningen, University of Groningen Groningen The Netherlands

R

Rick Brandsma

Department of Neurology University Medical Center Groningen, University of Groningen Groningen The Netherlands

R

Roelineke J. Lunsing

Department of Neurology University Medical Center Groningen, University of Groningen Groningen The Netherlands

H

Hendriekje Eggink

Department of Neurology University Medical Center Groningen, University of Groningen Groningen The Netherlands

H

Hendrik J. ter Horst

Department of Neonatology, Beatrix Children’s Hospital University Medical Center Groningen, University of Groningen Groningen The Netherlands

A

Arend F. Bos

Department of Neonatology, Beatrix Children’s Hospital University Medical Center Groningen, University of Groningen Groningen The Netherlands

D

Deborah A. Sival

Department of Pediatrics, Beatrix Children’s Hospital University Medical Center Groningen Groningen The Netherlands

Cite This Article

Marieke J. Kuiper, Rick Brandsma, Roelineke J. Lunsing, et al. (2018). The neurological phenotype of developmental motor patterns during early childhood. Brain and Behavior, 9(1). https://doi.org/10.1002/brb3.1153

The neurological phenotype of developmental motor patterns during early childhood

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