Unilateral disruptions in the default network with aging in native space

Qolamreza R. Razlighi; Christian Habeck; Jason Steffener; Yunglin Gazes; Laura B. Zahodne; Anna MacKay‐Brandt; Yaakov Stern

doi:10.1002/brb3.202

journal article Open Access Dec 29, 2013

Unilateral disruptions in the default network with aging in native space

Qolamreza R. Razlighi Christian Habeck Jason Steffener Yunglin Gazes Laura B. Zahodne Anna MacKay‐Brandt Yaakov Stern

Brain and Behavior Vol. 4 No. 2 pp. 143-157 · Wiley

View at Publisher Save 10.1002/brb3.202

Abstract

AbstractBackgroundDisruption of the default‐mode network (DMN) in healthy elders has been reported in many studies.MethodsIn a group of 51 participants (25 young, 26 elder) we examined DMN connectivity in subjects' native space. In the native space method, subject‐specific regional masks (obtained independently for each subject) are used to extract regional fMRI times series. This approach substitutes the spatial normalization and subsequent smoothing used in prevailing methods, affords more accurate spatial localization, and provides the power to examine connectivity separately in the two hemispheres instead of averaging regions across hemispheres.ResultsThe native space method yielded new findings which were not detectable by the prevailing methods. The most reliable and robust disruption in elders' DMN connectivity were found between supramarginal gyrus and superior‐frontal cortex in the right hemisphere only. The mean correlation between these two regions in young participants was about 0.5, and dropped significantly to 0.04 in elders (P = 2.1 × 10−5). In addition, the magnitude of functional connectivity between these regions in the right hemisphere correlated with memory (P = 0.05) and general fluid ability (P = 0.01) in elder participants and with speed of processing in young participants (P = 0.008). These relationships were not observed in the left hemisphere.ConclusionThese findings suggest that analysis of DMN connectivity in subjects' native space can improve localization and power and that it is important to examine connectivity separately in each hemisphere.

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References

Details

Published: Dec 29, 2013
Vol/Issue: 4(2)
Pages: 143-157
License: View

Authors

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Qolamreza R. Razlighi