Integrating natural compounds and nanoparticle‐based drug delivery systems: A novel strategy for enhanced efficacy and selectivity in cancer therapy

Asma Manzari‐Tavakoli; Amirhesam Babajani; Maryam Manzari Tavakoli; Fahimeh Safaeinejad; Ameneh Jafari

doi:10.1002/cam4.7010

journal article Open Access Mar 01, 2024

Integrating natural compounds and nanoparticle‐based drug delivery systems: A novel strategy for enhanced efficacy and selectivity in cancer therapy

Asma Manzari‐Tavakoli Amirhesam Babajani

Maryam Manzari Tavakoli Fahimeh Safaeinejad Ameneh Jafari

Cancer Medicine Vol. 13 No. 5 · Wiley

View at Publisher Save 10.1002/cam4.7010

Abstract

AbstractCancer remains a leading cause of death worldwide, necessitating the development of innovative and more effective treatment strategies. Conventional cancer treatments often suffer from limitations such as systemic toxicity, poor pharmacokinetics, and drug resistance. Recently, there has been growing attention to utilizing natural compounds derived from various sources as possible cancer therapeutics. Natural compounds have demonstrated diverse bioactive properties, including antioxidant, anti‐inflammatory, and antitumor effects, making them attractive candidates for cancer treatment. However, their limited solubility and bioavailability present challenges for effective delivery to cancer cells. To overcome these limitations, researchers have turned to nanotechnology‐based drug delivery systems. Nanoparticles, with their small size and unique properties, can encapsulate therapeutic agents and offer benefits such as improved solubility, prolonged drug release, enhanced cellular uptake, and targeted delivery. Functionalizing nanoparticles with specific ligands further enhances their precision in recognizing and binding to cancer cells. Combining natural compounds with nanotechnology holds great promise in achieving efficient and safe cancer treatments by enhancing bioavailability, pharmacokinetics, and selectivity toward cancer cells. This review article provides an overview of the advancements in utilizing natural substances and nanotechnology‐based drug delivery systems for cancer treatment. It discusses the benefits and drawbacks of various types of nanoparticles, as well as the characteristics of natural compounds that make them appealing for cancer therapy. Additionally, current research on natural substances and nanoparticles in preclinical and clinical settings is highlighted. Finally, the challenges and future perspectives in developing natural compound‐nanoparticle‐based cancer therapies are discussed.

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References

119

[1]

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

Hyuna Sung, Jacques Ferlay, Rebecca L. Siegel et al.

CA: A Cancer Journal for Clinicians 10.3322/caac.21660

[2]

10.3390/pharmaceutics15030889

[3]

10.3389/fbioe.2020.00748

[4]

10.1021/cr900019j

[5]

10.1016/j.lfs.2020.117463

[6]

10.1016/b978-0-12-398456-2.00004-9

[7]

10.1016/j.prp.2023.154427

[8]

Jafari A "Silver nanoparticles inhibit proliferation and migration of prostate cancer cells: an experimental report" World Canc Res J (2022)

[9]

10.1177/1559325820936161

[10]

Jafari A "Herbal extract incorporated chitosan based nanofibers as a new strategy for smart anticancer drug delivery system: an in vitro model" World Canc Res J (2020)

[11]

10.1038/s41598-022-22562-w

[12]

10.1080/10408398.2020.1738999

[13]

10.3389/fmolb.2020.00193

[14]

Nano based drug delivery systems: recent developments and future prospects

Jayanta Kumar Patra, Gitishree Das, Leonardo Fernandes Fraceto et al.

Journal of Nanobiotechnology 10.1186/s12951-018-0392-8

[15]

10.2147/ijn.s146315

[16]

10.3390/cancers13040670

[17]

10.1021/acsptsci.2c00033

[18]

10.3390/ijms24076615

[19]

10.1208/s12248-023-00807-4

[20]

10.2147/ott.s105587

[21]

10.3390/molecules26041109

[22]

Ghosh S "Novel bioactive compounds from marine sources as a tool for functional food development. Frontiers in marine" Science (2022)

[23]

10.3390/antiox10091455

[24]

10.1111/ajco.13941

[25]

10.1155/2022/5794350

[26]

Kumari A "Nanoencapsulation for drug delivery" Excli J (2014)

[27]

10.1080/10717544.2022.2089296

[28]

Controlled drug delivery vehicles for cancer treatment and their performance

Sudipta Senapati, Arun Kumar Mahanta, Sunil Kumar et al.

Signal Transduction and Targeted Therapy 10.1038/s41392-017-0004-3

[29]

10.1016/j.jcou.2021.101839

[30]

10.1016/j.colsurfb.2022.112707

[31]

10.1016/j.fpsl.2022.100872

[32]

10.1096/fj.201900945r

[33]

10.1007/s11130-015-0479-4

[34]

Bars‐Cortina D (2021)

[35]

10.3390/cells11071070

[36]

10.1002/cbdv.202200447

[37]

10.3390/ijms23147905

[38]

Diaconeasa Z "Anthocyanins, vibrant color pigments, and their role in skin cancer prevention" Biomedicine (2020)

[39]

Exosomal formulation of anthocyanidins against multiple cancer types

Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan et al.

Cancer Letters 10.1016/j.canlet.2017.02.004

[40]

10.1016/j.clay.2020.105770

[41]

10.1007/s12032‐021‐01491‐0

[42]

Thibado SP "Anticancer effects of bilberry anthocyanins compared with NutraNanoSphere encapsulated bilberry anthocyanins" Mol Clin Oncol (2018)

[43]

10.1021/acsnano.8b03525

[44]

10.1158/1940-6207.capr-19-0362

[45]

10.1016/j.xphs.2020.09.046

[46]

Exosomal delivery of berry anthocyanidins for the management of ovarian cancer

Farrukh Aqil, Jeyaprakash Jeyabalan, Ashish K. Agrawal et al.

Food & Function 10.1039/c7fo00882a

[47]

10.1093/advances/nmab007

[48]

10.2174/1381612823666171115094557

[49]

Sharifi‐Rad J "Ellagic acid: a review on its natural sources, chemical stability, and therapeutic potential" Oxid Med Cell Longev (2022) 10.1155/2022/3848084

[50]

10.1016/j.foodres.2011.04.027

Showing 50 of 119 references

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Details

Published: Mar 01, 2024
Vol/Issue: 13(5)
License: View

Authors

A

Asma Manzari‐Tavakoli

Department of biology faculty of science Ferdowsi University of Mashhad Mashhad Iran

A

Amirhesam Babajani

Oncopathology Research Center, Department of Molecular Medicine, School of Medicine Iran University of Medical Sciences Tehran Iran

M

Maryam Manzari Tavakoli

Department of Phytochemistry Medicinal Plants and Drugs Research Institute, Shahid Beheshti University Tehran Iran

F

Fahimeh Safaeinejad

Traditional Medicine and Materia Medica Research Center Shahid Beheshti University of Medical Sciences Tehran Iran

A

Ameneh Jafari

Chronic Respiratory Diseases Research Center, NRITLD Shahid Beheshti University of Medical Sciences Tehran Iran

Cite This Article

Asma Manzari‐Tavakoli, Amirhesam Babajani, Maryam Manzari Tavakoli, et al. (2024). Integrating natural compounds and nanoparticle‐based drug delivery systems: A novel strategy for enhanced efficacy and selectivity in cancer therapy. Cancer Medicine, 13(5). https://doi.org/10.1002/cam4.7010

Integrating natural compounds and nanoparticle‐based drug delivery systems: A novel strategy for enhanced efficacy and selectivity in cancer therapy

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