Self‐Assembled DNA Nanocages Promote Cell Migration and Differentiation of Human Umbilical Vein Endothelial Cells**

Anjali Rajwar Gada; Payal Vaswani; Ramesh Singh; Dhiraj Bhatia

doi:10.1002/cbic.202200634

journal article Feb 28, 2023

Self‐Assembled DNA Nanocages Promote Cell Migration and Differentiation of Human Umbilical Vein Endothelial Cells**

Anjali Rajwar Gada Payal Vaswani Ramesh Singh

Dhiraj Bhatia

ChemBioChem Vol. 24 No. 7 · Wiley

View at Publisher Save 10.1002/cbic.202200634

Abstract

AbstractDNA nanocages have been explored for abilities to influence cellular behavior and functions. Recent times have seen the development of new emergent functionalities of DNA nanodevices as a class of biomaterials with an immense capacity to interface with biological systems and with vast potential in disease diagnosis and therapeutics. Being chemically robust and biocompatible in nature, DNA nanocages have been surface modified and structurally fine‐tuned to find emerging applications in the field of stem‐cell therapy and tissue regeneration. DNA nanocages can be used for therapeutic angiogenesis that involves the induction of blood vessel formation and can be used to treat ischemic diseases like stroke or heart failure. This work addresses the effect of DNA nanocages’ structural topology on their capacity to stimulate endothelial cell angiogenesis. We tested a panel of four DNA nanocage geometries and checked their potential on the differentiation of human umbilical vein endothelial cells (HUVECs). While different DNA nanocage geometries showed successful induction of angiogenesis and cell migration in HUVECs, tetrahedral DNA cages showed the maximum uptake and angiogenesis potential, thus indicating that not only the composition of materials, but also the 3D arrangement of ligands might play role in stimulating angiogenesis.

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Metrics

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Citations

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References

Details

Published: Feb 28, 2023
Vol/Issue: 24(7)
License: View

Authors

A

Anjali Rajwar Gada

Biological Engineering Indian Institute of Technology Gandhinagar Palaj Gandhinagar Gujarat 382355 India

P

Payal Vaswani

Biological Engineering Indian Institute of Technology Gandhinagar Palaj Gandhinagar Gujarat 382355 India

R

Ramesh Singh

Biological Engineering Indian Institute of Technology Gandhinagar Palaj Gandhinagar Gujarat 382355 India

D

Dhiraj Bhatia

Biological Engineering Indian Institute of Technology Gandhinagar Palaj Gandhinagar Gujarat 382355 India

Funding

Science and Engineering Research Board

Indian Institute of Technology Gandhinagar

Cite This Article

Anjali Rajwar Gada, Payal Vaswani, Ramesh Singh, et al. (2023). Self‐Assembled DNA Nanocages Promote Cell Migration and Differentiation of Human Umbilical Vein Endothelial Cells**. ChemBioChem, 24(7). https://doi.org/10.1002/cbic.202200634

Self‐Assembled DNA Nanocages Promote Cell Migration and Differentiation of Human Umbilical Vein Endothelial Cells**

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