“On‐Off” Switching of Functional Guest Molecules via Exchange of Natural Product Solubilizing Agents

Riku Kawasaki; Atsushi Ikeda

doi:10.1002/cbic.202300455

journal article Aug 11, 2023

“On‐Off” Switching of Functional Guest Molecules via Exchange of Natural Product Solubilizing Agents

Riku Kawasaki

Atsushi Ikeda

ChemBioChem Vol. 24 No. 21 · Wiley

View at Publisher Save 10.1002/cbic.202300455

Abstract

AbstractFor the development of delivery systems, the solubilization of hydrophobic guest molecules in water is an important yet challenging task. This can be achieved by preparing stable aqueous solutions with a high concentration of guest molecules using a natural product as a solubilizing agent and a mechanochemical high‐speed vibration milling apparatus as a solubilizing method. Various solubilizing agent‐guest molecule complexes can be obtained via the exchange between solubilizing agents, which enables the “on‐off” switching of the properties of functional guest molecules, such as fluorescence intensity, and photodynamic activity. In the exchange method, guest molecules can transfer into cell membranes such as lysosomes and exosomes. Therefore, the exchange method of the solubilizing agents not only creates novel solubilizing agent‐guest molecule complexes but also is applied to drug delivery systems.

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References

80

[1]

Cyclodextrin Drug Carrier Systems

Kaneto Uekama, Fumitoshi Hirayama, Tetsumi IRIE

Chemical Reviews 10.1021/cr970025p

[2]

10.3390/molecules23081936

[3]

Cyclodextrin as a magic switch in covalent and non-covalent anticancer drug release systems

Bingren Tian, Yumei Liu, Jiayue Liu

Carbohydrate Polymers 10.1016/j.carbpol.2020.116401

[4]

10.1002/adfm.201909049

[5]

10.3390/pharmaceutics14071375

[6]

10.1002/anie.200802453

[7]

10.1016/j.carbpol.2019.05.067

[8]

10.1016/j.ijbiomac.2022.09.116

[9]

10.1016/j.carbpol.2022.120311

[10]

10.1002/tcr.201000008

[11]

10.1016/j.addr.2015.10.004

[12]

Formulation of water-dispersible hydrophobic compound nanocomplexes with polypeptides via a supramolecular approach using a high-speed vibration milling technique

Shogo Kawamura, Riku Kawasaki, Shodai Hino et al.

RSC Advances 10.1039/d2ra06054j

[13]

10.1002/asia.202200879

[14]

10.1039/a904736k

[15]

10.1016/j.ijpharm.2021.120571

[16]

Liposome composition in drug delivery design, synthesis, characterization, and clinical application

Danielle E. Large, Rudolf G. Abdelmessih, Elizabeth A. Fink et al.

Advanced Drug Delivery Reviews 10.1016/j.addr.2021.113851

[17]

10.3390/molecules27041372

[18]

10.1007/s10847-013-0319-9

[19]

10.1039/c6ra18635a

[20]

10.1002/chem.201803657

[21]

10.1039/c39920000604

[22]

10.1016/0167-2738(94)90435-9

[23]

10.1016/0040-4039(94)88237-1

[24]

10.1021/ol4030343

[25]

10.1002/slct.201702319

[26]

10.1016/s0022-2836(65)80093-6

[27]

10.1021/ja00061a070

[28]

10.1021/j100064a035

[29]

10.1039/b507954c

[30]

10.1039/b701767g

[31]

10.1021/ja070243s

[32]

10.1002/asia.201100792

[33]

10.1002/chem.200801090

[34]

10.1021/ol8015918

[35]

10.1021/ml4001535

[36]

10.1039/c1cc15229g

[37]

10.1021/jo3027609

[38]

10.1246/cl.130515

[39]

10.1039/c3ob41513a

[40]

10.1246/cl.2010.1256

[41]

10.1021/jp5029905

[42]

10.1039/c7cc00302a

[43]

10.1021/acsmedchemlett.1c00691

[44]

10.1039/c6ob02343f

[45]

10.1083/jcb.103.1.171

[46]

10.1021/j100154a006

[47]

Photodynamic Activity of Liposomal Photosensitizers via Energy Transfer from Antenna Molecules to [60]Fullerene

Atsushi Ikeda, Motofusa Akiyama, Takuya Ogawa et al.

ACS Medicinal Chemistry Letters 10.1021/ml100021x

[48]

10.1002/chem.201800674

[49]

10.1039/d0na00132e

[50]

10.1039/c5ob00240k

Showing 50 of 80 references

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Details

Published: Aug 11, 2023
Vol/Issue: 24(21)
License: View

Authors

R

Riku Kawasaki

Applied Chemistry Program Graduate School of Advanced Science and Engineering Hiroshima University 1-4-1 Kagamiyama Higashi-Hiroshima Hiroshima 739-8527 Japan

A

Atsushi Ikeda

Applied Chemistry Program Graduate School of Advanced Science and Engineering Hiroshima University 1-4-1 Kagamiyama Higashi-Hiroshima Hiroshima 739-8527 Japan

Funding

Japan Science and Technology Agency

Cite This Article

Riku Kawasaki, Atsushi Ikeda (2023). “On‐Off” Switching of Functional Guest Molecules via Exchange of Natural Product Solubilizing Agents. ChemBioChem, 24(21). https://doi.org/10.1002/cbic.202300455

“On‐Off” Switching of Functional Guest Molecules via Exchange of Natural Product Solubilizing Agents

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