Phase Separation in Biological Systems: Implications for Disease Pathogenesis

Raj Dave; Kshipra Pandey; Ritu Patel; Raghu Solanki; Nidhi Gour; Dhiraj Bhatia

doi:10.1002/cbic.202400883

journal article Apr 16, 2025

Phase Separation in Biological Systems: Implications for Disease Pathogenesis

Raj Dave Kshipra Pandey Ritu Patel Raghu Solanki

Nidhi Gour

Dhiraj Bhatia

ChemBioChem Vol. 26 No. 11 · Wiley

View at Publisher Save 10.1002/cbic.202400883

Abstract

Phase separation is the phenomenon where distinct liquid phases, within solution, play a critical role in the organization and function of biomolecular condensates within cells. Dysregulation of phase separation has been implicated, which can be witnessed in various diseases including neurodegenerative disorders, metabolic syndromes, and cancer. This review provides a comprehensive analysis of the role of phase separation in disease pathogenesis, which focuses on single amino acids, carbohydrates, and nucleotides. Molecular mechanisms underlying phase separation are also discussed with specific examples of diseases associated with dysregulated phase separation. Furthermore, consideration of therapeutic strategies targeting phase separation for disease intervention is explored.

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Details

Published: Apr 16, 2025
Vol/Issue: 26(11)
License: View

Authors

R

Raj Dave

Department of Chemistry Indrashil University Kadi Mehsana Gujarat 382740 India

K

Kshipra Pandey

Department of Biosciences Indrashil University Kadi Mehsana Gujarat 382740 India

R

Ritu Patel

Department of Biosciences Indrashil University Kadi Mehsana Gujarat 382740 India

R

Raghu Solanki

Department of Biological Sciences and Engineering Indian Institute of Technology Palaj Gujarat 382355 India

N

Nidhi Gour

Department of Chemistry Indrashil University Kadi Mehsana Gujarat 382740 India

D

Dhiraj Bhatia

Department of Biological Sciences and Engineering Indian Institute of Technology Palaj Gujarat 382355 India

Cite This Article

Raj Dave, Kshipra Pandey, Ritu Patel, et al. (2025). Phase Separation in Biological Systems: Implications for Disease Pathogenesis. ChemBioChem, 26(11). https://doi.org/10.1002/cbic.202400883

Phase Separation in Biological Systems: Implications for Disease Pathogenesis

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