APOBEC3G governs the generation of truncated AATF protein to ensure oncogenic transformation

Shaveta Sharma; Anuradha Garg; Rakesh S. Dhanda; Deepak Kaul

doi:10.1002/cbin.10681

journal article Oct 03, 2016

APOBEC3G governs the generation of truncated AATF protein to ensure oncogenic transformation

Shaveta Sharma Anuradha Garg Rakesh S. Dhanda Deepak Kaul

Cell Biology International Vol. 40 No. 12 pp. 1366-1371 · Wiley

View at Publisher Save 10.1002/cbin.10681

Abstract

AbstractThe oncogenic potential of Apolipoprotein B mRNA editing enzyme, catalytic polypeptide‐like 3G (APOBEC3G) was recently appreciated by the finding that revealed its ability to downregulate Kruppel‐like factor 4 (KLF4) gene translation through its affinity for 3′UTR of KLF4 mRNA. Keeping in view the fact that KLF4 is known to repress apoptosis antagonizing transcription factor (AATF) gene expression, the present study employed stem cells as archetype model to explore the effect of APOBEC3G over‐expression upon AATF gene expression within these cells as well as on the genes involved in oncogenic transformation. Such a study revealed that APOBEC3G had the ability to bind AATF mRNA within its third exon to facilitate the generation of truncated 23 kDa AATF translation product which, in turn, had the inherent capacity to be the crucial mediator of APOBEC3G induced oncogenic transformation within such cells.

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Metrics

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Citations

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References

Details

Published: Oct 03, 2016
Vol/Issue: 40(12)
Pages: 1366-1371
License: View

Authors

S

Shaveta Sharma

Department of Experimental Medicine and Biotechnology Postgraduate Institute of Medical Education and Research Chandigarh 160012 India

A

Anuradha Garg

Department of Experimental Medicine and Biotechnology Postgraduate Institute of Medical Education and Research Chandigarh 160012 India

R

Rakesh S. Dhanda

Department of Experimental Medicine and Biotechnology Postgraduate Institute of Medical Education and Research Chandigarh 160012 India

D

Deepak Kaul

Department of Experimental Medicine and Biotechnology Postgraduate Institute of Medical Education and Research Chandigarh 160012 India

Cite This Article

Shaveta Sharma, Anuradha Garg, Rakesh S. Dhanda, et al. (2016). APOBEC3G governs the generation of truncated AATF protein to ensure oncogenic transformation. Cell Biology International, 40(12), 1366-1371. https://doi.org/10.1002/cbin.10681

APOBEC3G governs the generation of truncated AATF protein to ensure oncogenic transformation

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