Ionic Co‐Crystal Formation as a Path Towards Chiral Resolution in the Solid State

Oleksii Shemchuk; Boryana K. Tsenkova; Dario Braga; M. Teresa Duarte; Vânia André; Fabrizia Grepioni

doi:10.1002/chem.201802446

journal article Jul 19, 2018

Ionic Co‐Crystal Formation as a Path Towards Chiral Resolution in the Solid State

Oleksii Shemchuk

Boryana K. Tsenkova Dario Braga

M. Teresa Duarte

Vânia André

Fabrizia Grepioni

Chemistry – A European Journal Vol. 24 No. 48 pp. 12564-12573 · Wiley

View at Publisher Save 10.1002/chem.201802446

Abstract

AbstractThe preparation and characterization of a whole family of hydrated ionic co‐crystals formed by both enantiopure l‐proline and racemic dl‐proline with LiX (X=Cl, Br, I) are reported. The chiral preference of the lithium cation for homochiral coordination, both in the formation of crystalline conglomerates (with Cl and Br) and racemates (with Cl and I), in which molecules of opposite chirality are confined to distinct crystal layers, is discussed. Dehydration processes for all hydrated crystals have also been investigated.

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Cited By

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Solid-state chiral resolution mediated by stoichiometry: crystallizing etiracetam with ZnCl2

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Metrics

24

Citations

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References

Details

Published: Jul 19, 2018
Vol/Issue: 24(48)
Pages: 12564-12573
License: View

Authors

O

Oleksii Shemchuk

Dipartimento di Chimica G. Ciamician Università di Bologna Via F. Selmi 2 40126 Bologna Italy

B

Boryana K. Tsenkova

Dipartimento di Chimica G. Ciamician Università di Bologna Via F. Selmi 2 40126 Bologna Italy; Centro de Química Estrutural Instituto Superior Técnico Avenida Rovisco Pais 1049-001 Lisboa Portugal

D

Dario Braga

Dipartimento di Chimica G. Ciamician Università di Bologna Via F. Selmi 2 40126 Bologna Italy

M

M. Teresa Duarte

Centro de Química Estrutural Instituto Superior Técnico Avenida Rovisco Pais 1049-001 Lisboa Portugal

V

Vânia André

Centro de Química Estrutural Instituto Superior Técnico Avenida Rovisco Pais 1049-001 Lisboa Portugal

F

Fabrizia Grepioni

Dipartimento di Chimica G. Ciamician Università di Bologna Via F. Selmi 2 40126 Bologna Italy

Cite This Article

Oleksii Shemchuk, Boryana K. Tsenkova, Dario Braga, et al. (2018). Ionic Co‐Crystal Formation as a Path Towards Chiral Resolution in the Solid State. Chemistry – A European Journal, 24(48), 12564-12573. https://doi.org/10.1002/chem.201802446

Ionic Co‐Crystal Formation as a Path Towards Chiral Resolution in the Solid State

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