Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers

Paul L.A. Gabbott; Tracy A. Warner; Paul R.L. Jays; Phillip Salway; Sarah J. Busby

doi:10.1002/cne.20738

journal article Sep 29, 2005

Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers

Paul L.A. Gabbott Tracy A. Warner Paul R.L. Jays Phillip Salway Sarah J. Busby

Journal of Comparative Neurology Vol. 492 No. 2 pp. 145-177 · Wiley

View at Publisher Save 10.1002/cne.20738

Abstract

AbstractThis paper describes the quantitative areal and laminar distribution of identified neuron populations projecting from areas of prefrontal cortex (PFC) to subcortical autonomic, motor, and limbic sites in the rat. Injections of the retrograde pathway tracer wheat germ agglutinin conjugated with horseradish peroxidase (WGA‐HRP) were made into dorsal/ventral striatum (DS/VS), basolateral amygdala (BLA), mediodorsal thalamus (MD), lateral hypothalamus (LH), mediolateral septum, dorsolateral periaqueductal gray, dorsal raphe, ventral tegmental area, parabrachial nucleus, nucleus tractus solitarius, rostral/caudal ventrolateral medulla, or thoracic spinal cord (SC). High‐resolution flat‐map density distributions of retrogradely labelled neurons indicated that specific PFC regions were differentially involved in the projections studied, with medial (m)PFC divided into dorsal and ventral sectors. The percentages that WGA‐HRP retrogradely labelled neurons composed of the projection neurons in individual layers of infralimbic (IL; area 25) prelimbic (PL; area 32), and dorsal anterior cingulate (ACd; area 24b) cortices were calculated. Among layer 5 pyramidal cells, approximately 27.4% in IL/PL/ACd cortices projected to LH, 22.9% in IL/ventral PL to VS, 18.3% in ACd/dorsal PL to DS, and 8.1% in areas IL/PL to BLA; and 37% of layer 6 pyramidal cells in IL/PL/ACd projected to MD. Data for other projection pathways are given. Multiple dual retrograde fluorescent tracing studies indicated that moderate populations (<9%) of layer 5 mPFC neurons projected to LH/VS, LH/SC, or VS/BLA. The data provide new quantitative information concerning the density and distribution of neurons involved in identified projection pathways from defined areas of the rat PFC to specific subcortical targets involved in dynamic goal‐directed behavior. J. Comp. Neurol. 492:145–177, 2005. © 2005 Wiley‐Liss, Inc.

Topics

No keywords indexed for this article. Browse by subject →

References

138

[1]

10.1016/0006-8993(92)91629-s

[2]

10.1002/cne.903110102

[3]

10.1007/bf00247590

[4]

10.1016/0306-4522(93)90242-8

[5]

10.1016/0006-8993(96)00155-2

[6]

10.1016/s0079-6123(08)63056-3

[7]

10.1002/cne.903160305

[8]

10.1093/cercor/13.9.968

[9]

Bolam JP (1992) 10.1093/oso/9780199633265.001.0001

[10]

10.1016/0166-4328(90)90167-d

[11]

Brodmann K (1909)

[12]

10.1016/0006-8993(85)90774-7

[13]

10.1002/cne.903630408

[14]

Projections from the Rat Prefrontal Cortex to the Ventral Tegmental Area: Target Specificity in the Synaptic Associations with Mesoaccumbens and Mesocortical Neurons

David B. Carr, Susan R. Sesack

The Journal of Neuroscience 10.1523/jneurosci.20-10-03864.2000

[15]

10.1002/cne.902790207

[16]

10.1016/0006-8993(81)90986-0

[17]

Cechetto DF "Subcortical sites mediating sympathetic responses from insular cortex in rats" Am J Physiol (1990)

[18]

Cechetto DF (1990) 10.1093/oso/9780195051063.003.0012

[19]

Prefrontal Cortical–Ventral Striatal Interactions Involved in Affective Modulation of Attentional Performance: Implications for Corticostriatal Circuit Function

Anastasia Christakou, Trevor W. Robbins, Barry J. Everitt

The Journal of Neuroscience 10.1523/jneurosci.0949-03.2004

[20]

Chudasama Y "Dissociable contributions of the orbitofrontal and infralimbic cortex to pavlovian autoshaping and discrimination reversal learning: further evidence for the functional heterogeneity of the rodent frontal cortex" J Neurosci (2003) 10.1523/jneurosci.23-25-08771.2003

[21]

10.1002/cne.903520407

[22]

10.1016/j.bbr.2003.09.025

[23]

10.1016/j.neubiorev.2004.09.006

[24]

Damasio A (1991) 10.1093/oso/9780195062847.003.0011

[25]

10.1016/0301-0082(92)90015-7

[26]

10.1016/s0166-4328(99)00168-0

[27]

10.1016/s0006-8993(01)02912-2

[28]

10.1016/0006-8993(87)90450-1

[29]

10.1016/s0006-8993(97)00076-0

[30]

10.1016/s0006-8993(00)01935-1

[31]

Floresco SB "Thalamic‐corticalstriatal circuitry subserves working memory during delayed responding on a radial arm maze" J Neurosci (1999) 10.1523/jneurosci.19-24-11061.1999

[32]

10.1002/1096-9861(20000710)422:4<556::aid-cne6>3.0.co;2-u

[33]

10.1002/cne.1105

[34]

Fry JC (1992)

[35]

10.1016/0006-8993(94)90024-8

[36]

10.1016/j.brainres.2003.08.054

[37]

Gabbott PLA "Local circuit neurons in the medial prefrontal cortex (area 24a,b,c 25 and 32) of the monkey: 1. Cell morphology and morphometrics" J Comp Neurol (1996) 10.1002/(sici)1096-9861(19960122)364:4<567::aid-cne1>3.0.co;2-1

[38]

Gabbott PLA "Local circuit neurons in the medial prefrontal cortex (area 24a,b,c 25 and 32) of the monkey: 2. Quantitative areal and laminar distributions" J Comp Neurol (1996) 10.1002/(sici)1096-9861(19960122)364:4<609::aid-cne2>3.0.co;2-7

[39]

10.1016/0006-8993(96)00437-4

[40]

Gabbott PLA "Amygdala input to prelimbic cortex (area 32) monosynaptically innervates a corticospinal pathway in the rat" J Auton Nerv Syst (1997)

[41]

Gabbott PLA "Limbic cortex in the rat: multiple descending parallel pathways to subcortical autonomic and limbic target regions" J Auton Nerv Syst (2000)

[42]

10.1002/cne.902590305

[43]

Gabbott PLA "Local‐circuit neurones in the medial prefrontal cortex (area 25, 32 and 24b) in the rat: morphology and quantitative distribution" J Comp Neurol (1997) 10.1002/(sici)1096-9861(19970127)377:4<465::aid-cne1>3.0.co;2-0

[44]

10.1016/j.brainres.2003.08.056

[45]

10.1002/cne.902930109

[46]

10.1002/cne.903030405

[47]

Gerfen CR (1996) 10.1016/s0924-8196(96)80004-2

[48]

10.1007/978-3-642-85007-3_7

[49]

10.1016/0896-6273(95)90304-6

[50]

Granon S "Involvement of the rat prefrontal cortex in cognition: a central role for the prelimbic area" Psychobiology (2000) 10.3758/bf03331981

Showing 50 of 138 references

Cited By

1,044

Cognition-enhancing and cognition-impairing doses of psychostimulants exert opposing actions on frontostriatal neural coding of delay in working memory

Robert C. Spencer, Andrea J. Martin · 2023

Neuropsychopharmacology

Corticostriatal stimulation compensates for medial frontal inactivation during interval timing

Eric B. Emmons, Morgan Kennedy · 2019

Scientific Reports

Inferring action-dependent outcome representations depends on anterior but not posterior medial orbitofrontal cortex

Laura A. Bradfield, Genevra Hart · 2018

Neurobiology of Learning and Memory

High-Frequency Deep Brain Stimulation of the Nucleus Accumbens Region Suppresses Neuronal Activity and Selectively Modulates Afferent Drive in Rat Orbitofrontal CortexIn Vivo

Clinton B. McCracken, Anthony A. Grace · 2007

The Journal of Neuroscience

Metrics

1,044

Citations

138

References

Details

Published: Sep 29, 2005
Vol/Issue: 492(2)
Pages: 145-177
License: View

Authors

Cite This Article

Paul L.A. Gabbott, Tracy A. Warner, Paul R.L. Jays, et al. (2005). Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers. Journal of Comparative Neurology, 492(2), 145-177. https://doi.org/10.1002/cne.20738

Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers

You May Also Like