Combining aperiodic 1/f slopes and brain simulation: An EEG/MEG proxy marker of excitation/inhibition imbalance in Alzheimer's disease

Pablo Martínez‐Cañada; Eduardo Perez‐Valero; Jesus Minguillon; Francisco Pelayo; Miguel A. López‐Gordo; Christian Morillas

doi:10.1002/dad2.12477

journal article Open Access Jul 01, 2023

Combining aperiodic 1/f slopes and brain simulation: An EEG/MEG proxy marker of excitation/inhibition imbalance in Alzheimer's disease

Pablo Martínez‐Cañada

Eduardo Perez‐Valero Jesus Minguillon Francisco Pelayo Miguel A. López‐Gordo Christian Morillas

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring Vol. 15 No. 3 · Wiley

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Abstract

AbstractINTRODUCTIONAccumulation and interaction of amyloid‐beta (Aβ) and tau proteins during progression of Alzheimer's disease (AD) are shown to tilt neuronal circuits away from balanced excitation/inhibition (E/I). Current available techniques for noninvasive interrogation of E/I in the intact human brain, for example, magnetic resonance spectroscopy (MRS), are highly restrictive (i.e., limited spatial extent), have low temporal and spatial resolution and suffer from the limited ability to distinguish accurately between different neurotransmitters complicating its interpretation. As such, these methods alone offer an incomplete explanation of E/I. Recently, the aperiodic component of neural power spectrum, often referred to in the literature as the ‘1/f slope’, has been described as a promising and scalable biomarker that can track disruptions in E/I potentially underlying a spectrum of clinical conditions, such as autism, schizophrenia, or epilepsy, as well as developmental E/I changes as seen in aging.METHODSUsing 1/f slopes from resting‐state spectral data and computational modeling, we developed a new method for inferring E/I alterations in AD.RESULTSWe tested our method on recent freely and publicly available electroencephalography (EEG) and magnetoencephalography (MEG) datasets of patients with AD or prodromal disease and demonstrated the method's potential for uncovering regional patterns of abnormal excitatory and inhibitory parameters.DISCUSSIONOur results provide a general framework for investigating circuit‐level disorders in AD and developing therapeutic interventions that aim to restore the balance between excitation and inhibition.

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Published: Jul 01, 2023
Vol/Issue: 15(3)
License: View

Authors

P

Pablo Martínez‐Cañada

Department of Computer Engineering Automation and Robotics University of Granada Granada Spain; Research Centre for Information and Communications Technologies (CITIC) University of Granada Granada Spain

E

Eduardo Perez‐Valero

Department of Computer Engineering Automation and Robotics University of Granada Granada Spain; Research Centre for Information and Communications Technologies (CITIC) University of Granada Granada Spain

J

Jesus Minguillon

Research Centre for Information and Communications Technologies (CITIC) University of Granada Granada Spain; Department of Signal Theory Telematics and Communications University of Granada Granada Spain

F

Francisco Pelayo

Department of Computer Engineering Automation and Robotics University of Granada Granada Spain; Research Centre for Information and Communications Technologies (CITIC) University of Granada Granada Spain

M

Miguel A. López‐Gordo

Research Centre for Information and Communications Technologies (CITIC) University of Granada Granada Spain; Department of Signal Theory Telematics and Communications University of Granada Granada Spain

C

Christian Morillas

Department of Computer Engineering Automation and Robotics University of Granada Granada Spain; Research Centre for Information and Communications Technologies (CITIC) University of Granada Granada Spain

Cite This Article

Pablo Martínez‐Cañada, Eduardo Perez‐Valero, Jesus Minguillon, et al. (2023). Combining aperiodic 1/f slopes and brain simulation: An EEG/MEG proxy marker of excitation/inhibition imbalance in Alzheimer's disease. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 15(3). https://doi.org/10.1002/dad2.12477

Combining aperiodic 1/f slopes and brain simulation: An EEG/MEG proxy marker of excitation/inhibition imbalance in Alzheimer's disease

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