Clear‐cell sarcoma diagnosis by fine‐needle aspiration: Cytologic, histologic, and ultrastructural features; potential pitfalls; and literature review

Tommy R. Tong; Tat‐chong Chow; Olivia Wai‐hing Chan; Kam‐cheong Lee; Sai‐hung Yeung; Angus Lam; Chi‐kin Yu

doi:10.1002/dc.10081

journal article Feb 27, 2002

Clear‐cell sarcoma diagnosis by fine‐needle aspiration: Cytologic, histologic, and ultrastructural features; potential pitfalls; and literature review

Tommy R. Tong Tat‐chong Chow Olivia Wai‐hing Chan Kam‐cheong Lee Sai‐hung Yeung Angus Lam Chi‐kin Yu

Diagnostic Cytopathology Vol. 26 No. 3 pp. 174-180 · Wiley

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Abstract

AbstractA definitive diagnosis of clear‐cell sarcoma of soft parts (CCSSP) is possible by fine‐needle aspiration (FNA) biopsy alone. The aspirates are markedly cellular, consisting predominantly of discohesive cells but also of cohesive cells. The cytoplasm is eosinophilic and eccentric. The nuclei are round and contain macronucleoli. CCSSP should be considered when FNA of a soft‐tissue tumor shows uncharacteristically high cellularity and relatively uniform cells with macronucleoli. Cohesion of some tumor cells does not rule out CCSSP. Melanin pigment and cytoplasmic clearing are infrequent and not necessary for the diagnosis. Sufficient material should always be procured for immunohistochemical studies on the cell block. Seven other cases are found in the literature, all correctly diagnosed by FNA. Although it is rare, CCSSP is a highly malignant tumor that can be diagnosed readily by FNA without resorting to incisional biopsy. Diagn. Cytopathol. 2002;26:174–180; DOI 10.1002/dc.10081 © 2002 Wiley‐Liss, Inc.

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Details

Published: Feb 27, 2002
Vol/Issue: 26(3)
Pages: 174-180
License: View

Authors

Cite This Article

Tommy R. Tong, Tat‐chong Chow, Olivia Wai‐hing Chan, et al. (2002). Clear‐cell sarcoma diagnosis by fine‐needle aspiration: Cytologic, histologic, and ultrastructural features; potential pitfalls; and literature review. Diagnostic Cytopathology, 26(3), 174-180. https://doi.org/10.1002/dc.10081

Clear‐cell sarcoma diagnosis by fine‐needle aspiration: Cytologic, histologic, and ultrastructural features; potential pitfalls; and literature review

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