Phytochemical conjugation as a potential semisynthetic approach toward reactive and reuse of obsolete sulfonamides against pathogenic bacteria

Shasank S. Swain; Sudhir K. Paidesetty; Rabindra N. Padhy

doi:10.1002/ddr.21746

journal article Oct 06, 2020

Phytochemical conjugation as a potential semisynthetic approach toward reactive and reuse of obsolete sulfonamides against pathogenic bacteria

Shasank S. Swain

Sudhir K. Paidesetty

Rabindra N. Padhy

Drug Development Research Vol. 82 No. 2 pp. 149-166 · Wiley

View at Publisher Save 10.1002/ddr.21746

Abstract

AbstractThe emergence and reemergence of multidrug‐resistant (MDR) bacteria and mycobacteria in community and hospital periphery have directly enhanced the hospitalization costs, morbidity and mortality, globally. The appearance of MDR pathogens, the currently used antibiotics, remains insufficient, and the development of potent antibacterial(s) is merely slow. Thus, the development of active antibacterials is the call of the day. The sulfonamides class of antibacterials was the most successful synthesized drug in the 19th century. Mechanically, sulfonamides were targeting bacterial folic acid biosynthesis and today, those are obsolete or clinically inactive. Nevertheless, the magic sulfonamide pharmacophore has been used continuously in several mainstream antibacterial, antidiabetic, antiviral drugs. Concomitantly, thousands of phytochemicals with antimicrobial potencies have been recorded and were commanded as alternate antibacterials toward control of MDR pathogens. However, none/very few isolated phytochemicals have gone up to the pure‐drug stage due to the lack of the desired drug‐likeness values and the required pharmacokinetic properties. Thus, chemical modification of parent drug remains as the versatile approach in antibacterial drug development. Improvement of clinically inactive sulfa drugs with suitable phytochemicals to develop active, low‐toxic drug molecules followed by medicinal chemistry could be prudent. This review highlights such “sulfonamide‐phytochemical” hybrid drug development research works for utilizing inactive sulfonamides and phytochemicals; the ingenious cost‐effective and resource‐saving hybrid drug concept could be a new trend in current antibacterial drug discovery to reactive the obsolete antibacterials.

Topics

No keywords indexed for this article. Browse by subject →

References

122

[1]

10.1039/c2np20035j

[2]

10.1016/j.micres.2006.06.010

[3]

10.1002/9780470920541.ch2

[4]

10.1016/j.bmcl.2019.06.041

[5]

10.3998/ark.5550190.0010.611

[6]

10.1016/j.saa.2012.08.043

[7]

10.1016/j.biotechadv.2015.08.001

[8]

10.1016/j.micres.2016.12.003

[9]

10.3109/14756366.2015.1134524

[10]

10.1016/j.ejmech.2009.12.022

[11]

10.4161/mabs.26632

[12]

10.1016/j.critrevonc.2016.11.009

[13]

10.1136/bmj.h2879

[14]

10.1016/j.bmc.2011.02.032

[15]

10.1016/j.mib.2015.05.008

[16]

10.1021/bc200212a

[17]

10.1016/j.molstruc.2014.05.066

[18]

10.1128/aac.00361-10

[19]

10.1111/j.1574-6976.2011.00295.x

[20]

10.1007/s11101-016-9488-7

[21]

10.3109/14756366.2013.787422

[22]

10.4103/phrev.phrev_21_17

[23]

10.1016/j.fitote.2015.04.012

[24]

10.3109/14756366.2011.574623

[25]

10.1080/14756360600810340

[26]

10.1016/j.ejmech.2009.11.029

[27]

10.1093/jac/dks436

[28]

10.1128/cmr.12.4.564

[29]

10.1016/j.jep.2005.05.011

[30]

10.1016/j.bbagen.2013.02.008

[31]

10.1007/s11101-020-09659-8

[32]

10.1128/mmbr.00016-10

[33]

10.1371/journal.pmed.1002184

[34]

10.1016/s0924-8579(01)00470-8

[35]

10.3390/metabo2020303

[36]

10.1016/j.drudis.2008.10.011

[37]

Antibiotics and Bacterial Resistance in the 21st Century

Richard J. Fair, Yitzhak Tor

Perspectives in Medicinal Chemistry 10.4137/pmc.s14459

[38]

10.4315/0362-028x-68.8.1664

[39]

10.1016/j.jep.2012.02.029

[40]

10.1093/femsre/fux007

[41]

10.2174/156802607779941323

[42]

10.2174/092986712799945021

[43]

10.1515/jtim-2017-0007

[44]

10.1111/j.1750-3841.2010.01985.x

[45]

10.1007/s11101-019-09607-1

[46]

10.3389/fmicb.2018.01369

[47]

10.1080/13543776.2018.1487400

[48]

10.1016/j.molstruc.2016.03.092

[49]

10.1016/j.bmc.2010.08.039

[50]

10.1093/femsec/fiv169

Showing 50 of 122 references

Cited By

23

Design and synthesis of phyto-Saxagliptin conjugates: Targeting DPP IV, AChE, and β-amyloid in cognitive impairment

Swagata Pattanaik, Sudhir Kumar Paidesetty · 2025

Journal of Molecular Structure

Antimicrobial Resistance in Escherichia coli Strains Isolated from Humans and Pet Animals

Nikola Puvača, Rosa de Llanos Frutos · 2021

Antibiotics

Metrics

23

Citations

122

References

Details

Published: Oct 06, 2020
Vol/Issue: 82(2)
Pages: 149-166
License: View

Authors

S

Shasank S. Swain

Central Research Laboratory Institute of Medical Sciences and Sum Hospital, Siksha ‘O’ Anusandhan Deemed to be University Bhubaneswar Odisha India

S

Sudhir K. Paidesetty

Department of Pharmaceutical Chemistry School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan Deemed to be University Bhubaneswar Odisha India

R

Rabindra N. Padhy

Central Research Laboratory Institute of Medical Sciences and Sum Hospital, Siksha ‘O’ Anusandhan Deemed to be University Bhubaneswar Odisha India

Cite This Article

Shasank S. Swain, Sudhir K. Paidesetty, Rabindra N. Padhy (2020). Phytochemical conjugation as a potential semisynthetic approach toward reactive and reuse of obsolete sulfonamides against pathogenic bacteria. Drug Development Research, 82(2), 149-166. https://doi.org/10.1002/ddr.21746

Phytochemical conjugation as a potential semisynthetic approach toward reactive and reuse of obsolete sulfonamides against pathogenic bacteria

You May Also Like