Glycemic variability in the development of cardiovascular complications in diabetes

Annunziata Nusca; Dario Tuccinardi; Marzia Albano; Camilla Cavallaro; Elisabetta Ricottini; Silvia Manfrini; Paolo Pozzilli; Germano Di Sciascio

doi:10.1002/dmrr.3047

journal article Aug 09, 2018

Glycemic variability in the development of cardiovascular complications in diabetes

Annunziata Nusca

Dario Tuccinardi Marzia Albano Camilla Cavallaro Elisabetta Ricottini Silvia Manfrini Paolo Pozzilli

Germano Di Sciascio

Diabetes/Metabolism Research and Reviews Vol. 34 No. 8 · Wiley

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Abstract

SummaryDiabetes mellitus represents a major risk factor for the development of coronary artery disease and other vascular complications. Glycated haemoglobin, fructosamine, and fasting blood glucose levels are partial parameters to exhaustively describe patient dysglycemic status. Thus, recently the new concept of glycemic variability has emerged, including information about two major aspects: the magnitude of blood glucose excursions (from nadir to peak, thus lower and higher spikes) and the time intervals in which these fluctuations occur. Despite the lack of consensus regarding the most appropriate definition and tools for its assessment, glycemic variability seems to have more deleterious effects than sustained hyperglycemia in the pathogenesis of diabetic cardiovascular complications. This manuscript aimed to review the most recent evidence on glycemic variability and its potential use in everyday clinical practice to identify diabetic patients at higher risk of cardiovascular complications and thus needing stricter monitoring and treatment.

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Details

Published: Aug 09, 2018
Vol/Issue: 34(8)
License: View

Authors

A

Annunziata Nusca

Unit of Cardiac Sciences Campus Bio‐Medico University of Rome Rome Italy

D

Dario Tuccinardi

Unit of Endocrinology and Diabetes Department of Medicine Campus Bio‐Medico University of Rome Rome Italy

M

Marzia Albano

Unit of Cardiac Sciences Campus Bio‐Medico University of Rome Rome Italy

C

Camilla Cavallaro

Unit of Cardiac Sciences Campus Bio‐Medico University of Rome Rome Italy

E

Elisabetta Ricottini

Unit of Cardiac Sciences Campus Bio‐Medico University of Rome Rome Italy

S

Silvia Manfrini

Unit of Endocrinology and Diabetes Department of Medicine Campus Bio‐Medico University of Rome Rome Italy

P

Paolo Pozzilli

Unit of Endocrinology and Diabetes Department of Medicine Campus Bio‐Medico University of Rome Rome Italy

G

Germano Di Sciascio

Unit of Cardiac Sciences Campus Bio‐Medico University of Rome Rome Italy

Cite This Article

Annunziata Nusca, Dario Tuccinardi, Marzia Albano, et al. (2018). Glycemic variability in the development of cardiovascular complications in diabetes. Diabetes/Metabolism Research and Reviews, 34(8). https://doi.org/10.1002/dmrr.3047

Glycemic variability in the development of cardiovascular complications in diabetes

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