Incidence and trend of type 1 diabetes and the underlying environmental determinants

Ying Xia; Zhiguo Xie; Gan Huang; Zhiguang Zhou

doi:10.1002/dmrr.3075

journal article Oct 11, 2018

Incidence and trend of type 1 diabetes and the underlying environmental determinants

Ying Xia

Zhiguo Xie Gan Huang

Zhiguang Zhou

Diabetes/Metabolism Research and Reviews Vol. 35 No. 1 · Wiley

View at Publisher Save 10.1002/dmrr.3075

Abstract

SummaryA wealth of epidemiological studies concerning the distribution of type 1 diabetes (T1D) around the world have pointed to the appreciable variation in the incidence of T1D among disparate age groups, ethnicities, and geographical locations. On the whole, the incidence of childhood T1D has been on the rise, and a plausible inverse relationship between the initial incidence rate and the following annual increase in incidence has been raised. Countries that used to exhibit lower incidences tend to have steep annual increase whereas those with already‐established high incidences are more likely to show a modest increase or even stabilization in T1D incidence. Environmental agents considered responsible for the current evolving pattern of T1D incidence will be detailed, mainly including the increasing prevalence of childhood obesity, viral infections in a chronic manner, maternal‐child interaction such as breastfeeding, and latitude‐ultraviolet B‐vitamin D pathway. Certain rationale has been put forward in an attempt to explain the potential association between environmental agents and development of T1D. For instance, accelerator hypothesis regards insulin resistance as the promoter of earlier disease onset in obese children whereas the negative correlation of microbial infections in background populations with incidence of T1D represents the basic component of the hygiene hypothesis. Further investigations are still warranted to verify these theories across multiple ethnic groups and to identify additional contributors to the variation in T1D incidence.

Topics

No keywords indexed for this article. Browse by subject →

References

89

[1]

10.1016/s0140-6736(13)60591-7

[2]

10.2337/db10-0813

[3]

10.1111/j.1399-5448.2011.00765.x

[4]

10.1111/j.1399-5448.2012.00858.x

[5]

10.1001/jama.2013.8399

[6]

10.2337/db12-1771

[7]

10.1007/s00125-013-3090-y

[8]

10.1111/dme.12407

[9]

10.1007/s00125-015-3709-2

[10]

10.1111/dme.13295

[11]

10.1007/s00431-016-2787-6

[12]

10.1111/pedi.12354

[13]

10.2337/dc08-0239

[14]

10.1007/s00125-011-2244-z

[15]

Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults

Leandra Abarca-Gómez, Ziad A Abdeen, Zargar Abdul Hamid et al.

The Lancet 10.1016/s0140-6736(17)32129-3

[16]

10.1007/s00125-017-4365-5

[17]

10.1111/j.1464-5491.2011.03288.x

[18]

10.1111/pedi.12101

[19]

10.4274/jcrpe.1171

[20]

10.1111/pedi.12197

[21]

10.1111/pedi.12324

[22]

10.1016/j.diabres.2017.03.014

[23]

10.2337/diacare.21.4.525

[24]

10.1136/bmj.j5295

[25]

10.1007/s00592-014-0590-2

[26]

10.1186/1756-0500-5-628

[27]

10.1111/pedi.12480

[28]

10.2337/db13-1891

[29]

10.1016/j.diabres.2017.03.014

[30]

10.1007/s00431-015-2537-1

[31]

10.1371/journal.pone.0032640

[32]

10.1111/apa.12949

[33]

10.1371/journal.pone.0183665

[34]

10.1111/j.1399-5448.2011.00826.x

[35]

10.1111/j.1399-5448.2012.00898.x

[36]

10.1016/j.diabet.2008.06.002

[37]

10.1111/j.1464-5491.2008.02508.x

[38]

10.1111/dme.13063

[39]

Sipetic S "Rising incidence of type 1 diabetes in Belgrade children aged 0‐14 years in the period from 1982 to 2005" J Endocrinol Invest (2013)

[40]

10.1002/dmrr.558

[41]

10.1111/dme.12701

[42]

10.1111/pedi.12636

[43]

10.2337/dc12-0844

[44]

10.1186/s12889-015-1591-y

[45]

10.1007/s001250051573

[46]

10.1007/s00125-012-2571-8

[47]

10.1111/j.1464-5491.2006.01925.x

[48]

10.1001/jama.2014.3201

[49]

10.1111/j.1399-5448.2007.00255.x

[50]

10.1371/journal.pone.0132716

Showing 50 of 89 references

Cited By

98

The SAGE study: Global observational analysis of glycaemic control, hypoglycaemia and diabetes management in T1DM

Eric Renard, Hiroshi Ikegami · 2021

Diabetes/Metabolism Research and Re...

Metrics

98

Citations

89

References

Details

Published: Oct 11, 2018
Vol/Issue: 35(1)
License: View

Authors

Y

Ying Xia

Department of Metabolism & Endocrinology, The Second Xiangya Hospital Central South University Changsha Hunan China; Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education; National Clinical Research Center for Metabolic Diseases Changsha Hunan China

Z

Zhiguo Xie

Department of Metabolism & Endocrinology, The Second Xiangya Hospital Central South University Changsha Hunan China; Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education; National Clinical Research Center for Metabolic Diseases Changsha Hunan China

G

Gan Huang

Department of Metabolism & Endocrinology, The Second Xiangya Hospital Central South University Changsha Hunan China; Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education; National Clinical Research Center for Metabolic Diseases Changsha Hunan China

Z

Zhiguang Zhou

Department of Metabolism & Endocrinology, The Second Xiangya Hospital Central South University Changsha Hunan China; Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education; National Clinical Research Center for Metabolic Diseases Changsha Hunan China

Funding

National Natural Science Foundation of China Award: No. 81400783

Central South University Award: ZLXD2016003

Cite This Article

Ying Xia, Zhiguo Xie, Gan Huang, et al. (2018). Incidence and trend of type 1 diabetes and the underlying environmental determinants. Diabetes/Metabolism Research and Reviews, 35(1). https://doi.org/10.1002/dmrr.3075

Incidence and trend of type 1 diabetes and the underlying environmental determinants

You May Also Like