Glucose patterns following alcohol and illicit drug use in young adults with type 1 diabetes: A flash glucose monitoring study

Adam Pastor; Jennifer Conn; Margaret Loh; Casey L O'Brien; Jessie Teng; Sue Finch; Lisa Collins; Richard J MacIsaac; Yvonne Bonomo

doi:10.1002/edm2.257

journal article Open Access May 06, 2021

Glucose patterns following alcohol and illicit drug use in young adults with type 1 diabetes: A flash glucose monitoring study

Adam Pastor

Jennifer Conn Margaret Loh Casey L O'Brien Jessie Teng Sue Finch Lisa Collins Richard J MacIsaac Yvonne Bonomo

Endocrinology, Diabetes & Metabolism Vol. 4 No. 3 · Wiley

View at Publisher Save 10.1002/edm2.257

Abstract

AbstractIntroductionTo assess the effects of alcohol and illicit drug use in young adults (age 18–35) with type 1 diabetes (T1D) on flash glucose monitor sensor glucose (SG) readings.MethodsTwenty young adults with T1D were enrolled from a tertiary referral hospital outpatient department in Melbourne, Australia for a 6‐week prospective observational study using flash glucose monitoring (FGM). Glucometrics comparing substance using days (SUEDs) to those without substance use (non‐SUEDS) were analysed. The primary outcomes were the difference in mean SG values, its standard deviation and minutes/24‐h period out of range (SG <3.9 mmol/L or >10.0 mmol/L) between matched SUEDs vs non‐SUEDs. An interaction model with the primary effect of HbA1c on SG values was also performed.ResultsThere were no differences in the primary outcome measures between SUEDS and non‐SUEDs. However, there were differences in the regression coefficients for HbA1c and glucometrics between non‐SUEDs and SUEDs for mean SG, time out of range and time with SG > 10 mmol/L. This difference was also identified between non‐SUEDS and days of ≥40 g alcohol for mean SG.ConclusionsWhile there was no difference between glucometrics for SUEDs and non‐SUEDs on primary outcomes, HbA1C was found to be a less reliable predictor of glucose patterns in the 24‐h period following substance use than control days. Young adults with T1D need to monitor and respond to their glucose levels following substance use and engage in harm minimisation practices irrespective of baseline glucose control.

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Details

Published: May 06, 2021
Vol/Issue: 4(3)
License: View

Authors

A

Adam Pastor

Department of Addiction Medicine St Vincent's Hospital Melbourne Fitzroy Vic. Australia; Department of Medicine University of Melbourne Parkville Vic. Australia

J

Jennifer Conn

Department of Medicine University of Melbourne Parkville Vic. Australia; Department of Diabetes and Endocrinology Royal Melbourne Hospital Parkville Vic. Australia

M

Margaret Loh

Department of Endocrinology and Diabetes St Vincent's Hospital Melbourne Fitzroy Vic. Australia

C

Casey L O'Brien

Mental Health Services St Vincent's Hospital Melbourne Fitzroy Vic. Australia; Department of Psychiatry University of Melbourne Parkville Vic. Australia

J

Jessie Teng

Department of Endocrinology and Diabetes St Vincent's Hospital Melbourne Fitzroy Vic. Australia

S

Sue Finch

School of Mathematics and Statistics University of Melbourne Parkville Vic. Australia

L

Lisa Collins

Department of Addiction Medicine St Vincent's Hospital Melbourne Fitzroy Vic. Australia

R

Richard J MacIsaac

Department of Medicine University of Melbourne Parkville Vic. Australia; Department of Endocrinology and Diabetes St Vincent's Hospital Melbourne Fitzroy Vic. Australia

Y

Yvonne Bonomo

Department of Addiction Medicine St Vincent's Hospital Melbourne Fitzroy Vic. Australia; Department of Medicine University of Melbourne Parkville Vic. Australia

Cite This Article

Adam Pastor, Jennifer Conn, Margaret Loh, et al. (2021). Glucose patterns following alcohol and illicit drug use in young adults with type 1 diabetes: A flash glucose monitoring study. Endocrinology, Diabetes & Metabolism, 4(3). https://doi.org/10.1002/edm2.257

Glucose patterns following alcohol and illicit drug use in young adults with type 1 diabetes: A flash glucose monitoring study

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