journal article Open Access Sep 04, 2022

Zinc nutrition and human health: Overview and implications

eFood Vol. 3 No. 5 · Wiley
Abstract
AbstractZinc deficiency, being the fifth leading risk factor for diseases is associated with several disorders and infections, especially diarrhea. The common strategies for sustaining zinc's bioavailability include food fortification, biofortification, supplementation, and dietary diversification. To obtain the best technique, we need to appraise ourselves of the causes of deficiency, zinc bioavailability modalities, potential enhancers as well as inhibitors. This review highlights the role of zinc in human health, its bioavailability, causes and consequences of deficiency, and the strategies to alleviate the deficiency. The strategy of supplementation is pertinent, mostly for the population for whom the usual diet is insufficient for replenishment, and in a short period, the zinc status has to be enhanced. For high‐risk groups, fortification could be targeted to prevent potent inhibitors from hindering zinc absorption. By biofortification, enhancement of zinc concentration can be obtained in the edible portion of plants. Germination, fermentation, addition of enhancers, and other processing techniques also help to increase zinc absorption. Dietary modification is found to be an economically feasible, equitable, and sustainable strategy, and can be used to mitigate zinc deficiencies without any antagonistic effect. These strategies should be integrated with health and nutrition programs to create awareness and education, to enhance their sustainability and effectiveness.
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References
213
[1]
Abbeddou S. "Small‐quantity lipid‐based nutrient supplements containing different amounts of zinc along with diarrhea and malaria treatment increase iron and vitamin A status and reduce anemia prevalence, but do not affect zinc status in young Burkinabe children: A cluster‐randomized trial" BMC Pediatrics (2017) 10.1186/s12887-016-0765-9
[2]
Abdollahi M. "Zinc supplementation is an effective and feasible strategy to prevent growth retardation in 6 to 24 month children: A pragmatic double blind, randomized trial" Heliyon (2019) 10.1016/j.heliyon.2019.e02581
[3]
Abid N. "Transgenic expression of phytase in wheat endosperm increases bioavailability of iron and zinc in grains" Transgenic Research (2017) 10.1007/s11248-016-9983-z
[5]
Aggarwal S. "RNAi‐mediated downregulation of inositol pentakisphosphate kinase (IPK1) in wheat grains decreases phytic acid levels and increases Fe and Zn accumulation" Frontiers in Plant Science (2018) 10.3389/fpls.2018.00259
[7]
Akram M. A. "Zinc application improves productivity and biofortification of mini core rice hybrids: Nuclear Institute of Agriculture, Tandojam, Pakistan" Pakistan Journal of Agriculture, Agricultural Engineering and Veterinary Sciences (2019)
[9]
Anandan A. "Genotypic variation and relationships between quality traits and trace elements in traditional and improved rice (Oryza sativa L.) genotypes" Journal of Food Science (2011) 10.1111/j.1750-3841.2011.02135.x
[10]
Andriollo‐Sanchez M. "Zinc intake and status in middle‐aged and older European subjects: The ZENITH study" European Journal of Clinical Nutrition (2005) 10.1038/sj.ejcn.1602296
[12]
Arabhanvi F. "Agronomic fortification with zinc and iron to enhancing micronutrient concentration in sweet corn grain to ameliorate the deficiency symptoms in human beings" International Journal of Current Microbiology and Applied Sciences (2018) 10.20546/ijcmas.2018.702.044
[13]
Arif M. "Effect of varieties and nutrient management on quality and zinc biofortification of wheat (Triticum aestivum)" Indian Journal of Agricultural Sciences (2019) 10.56093/ijas.v89i9.93492
[14]
Ayogu R. N. B. "Impact of cowpea fortified cookies on anthropometric and micronutrient status of primary school children: A randomized, single‐blind controlled trial" Nigerian Journal of Clinical Practice (2018) 10.4103/njcp.njcp_72_18
[16]
Badii A. "Effect of consuming zinc‐fortified bread on serum zinc and iron status of zinc‐deficient women: A double blind, randomized clinical trial" International Journal of Preventive Medicine (2012)
[17]
Balk J. "Improving wheat as a source of iron and zinc for global nutrition" Nutrition Bulletin (2019) 10.1111/nbu.12361
[18]
Bandillo N. "Multi‐parent advanced generation inter‐cross (MAGIC) populations in rice: Progress and potential for genetics research and breeding" Rice (2013) 10.1186/1939-8433-6-11
[19]
Banerjee S. "Use of in silico and semiquantitative RT‐PCR approaches to develop nutrient rich rice (Oryza sativa L.)" Indian Journal of Biotechnology (2010)
[20]
Beintema J. J. S. "Scaling‐up biofortified beans high in iron and zinc through the school‐feeding program: A sensory acceptance study with schoolchildren from two departments in southwest Colombia" Food Science & Nutrition (2018) 10.1002/fsn3.632
[21]
Bhatt R. "Zinc biofortification as an innovative technology to alleviate the zinc deficiency in human health: A review" Open Agriculture (2020) 10.1515/opag-2020-0018
[22]
Blair M. W. "Registration of high mineral common bean germplasm lines NUA35 and NUA56 from the red‐mottled seed class" Journal of Plant Registrations (2010) 10.3198/jpr2008.09.0562crg
[23]
Borrill P. "Biofortification of wheat grain with iron and zinc: Integrating novel genomic resources and knowledge from model crops" Frontiers in Plant Science (2014) 10.3389/fpls.2014.00053
[24]
Improving nutrition through biofortification: A review of evidence from HarvestPlus, 2003 through 2016

Howarth E. Bouis, Amy Saltzman

Global Food Security 2017 10.1016/j.gfs.2017.01.009
[25]
Brnić M. "Zinc absorption by adults is similar from intrinsically labeled zinc‐biofortified rice and from rice fortified with labeled zinc sulfate" The Journal of Nutrition (2016) 10.3945/jn.115.213421
[27]
Brown K. H. "Zinc fortification of cereal flours: Current recommendations and research needs" Food and Nutrition Bulletin (2010) 10.1177/15648265100311s106
[28]
Brown K. H. "Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: A meta‐analysis of randomized controlled trials" The American Journal of Clinical Nutrition (2002) 10.1093/ajcn/75.6.1062
[29]
Brown K. H. "International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control" Food and Nutrition Bulletin (2004)
[31]
Cakmak I. "Zinc and iron concentrations in seeds of wild, primitive, and modern wheats" Food and Nutrition Bulletin (2000) 10.1177/156482650002100411
[32]
Cambraia T. L. L. "Agronomic biofortification of common bean grain with zinc" Pesquisa Agropecuária Brasileira (2019) 10.1590/s1678-3921.pab2019.v54.01003
[34]
Carvalho L. J. "Iron and zinc retention in common beans (Phaseolus vulgaris L.) after home cooking" Food & Nutrition Research (2012) 10.3402/fnr.v56i0.15618
[35]
Chadare F. J. "Conventional and food‐to‐food fortification: An appraisal of past practices and lessons learned" Food Science & Nutrition (2019) 10.1002/fsn3.1133
[36]
Chao H.‐C. "Cut‐off serum zinc concentration affecting the appetite, growth, and nutrition status of undernourished children supplemented with zinc" Nutrition in Clinical Practice (2018) 10.1002/ncp.10079
[39]
Condomina J. "Kinetics of zinc transport in vitro in rat small intestine and colon: Interaction with copper" European Journal of Pharmaceutical Sciences (2002) 10.1016/s0928-0987(02)00125-2
[42]
Oliveira N. T. "Zinc biofortification strategies in food‐type soybean cultivars" Australian Journal of Crop Science (2019) 10.21475/ajcs.19.13.01.p783
[43]
Romana D. L. "Longitudinal measurements of zinc absorption in Peruvian children consuming wheat products fortified with iron only or iron and 1 of 2 amounts of zinc" The American Journal of Clinical Nutrition (2005) 10.1093/ajcn/81.3.637
[44]
De Valença A. W. "Agronomic biofortification of crops to fight hidden hunger in sub‐saharan Africa" Global Food Security (2017) 10.1016/j.gfs.2016.12.001
[46]
Merwe R. "Improving iron and zinc bioaccessibility through food‐to‐food fortification of pearl millet with tropical plant foodstuffs (moringa leaf powder, roselle calyces and baobab fruit pulp)" Journal of Food Science and Technology (2019) 10.1007/s13197-019-03711-y
[48]
Dhawi F. "Mycorrhiza and heavy metal resistant bacteria enhance growth, nutrient uptake and alter metabolic profile of sorghum grown in marginal soil" Chemosphere (2016) 10.1016/j.chemosphere.2016.04.112
[50]
Doolette C. L. "Foliar application of zinc sulphate and zinc EDTA to wheat leaves: Differences in mobility, distribution, and speciation" Journal of Experimental Botany (2018) 10.1093/jxb/ery236

Showing 50 of 213 references