Genotoxicity of lavender oil, linalyl acetate, and linalool on human lymphocytes in vitro

Antonella Di Sotto; Gabriela Mazzanti; Fabio Carbone; Patrizia Hrelia; Francesca Maffei

doi:10.1002/em.20587

journal article Jan 01, 2011

Genotoxicity of lavender oil, linalyl acetate, and linalool on human lymphocytes in vitro

Antonella Di Sotto

Gabriela Mazzanti Fabio Carbone Patrizia Hrelia Francesca Maffei

Environmental and Molecular Mutagenesis Vol. 52 No. 1 pp. 69-71 · Wiley

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Abstract

AbstractThe potential genotoxicity of lavender essential oil and its major components, linalool, and linalyl acetate, was evaluated in vitro by the micronucleus test on peripheral human lymphocytes. In the range of non‐toxic concentrations (0.5–100 μg/ml), linalyl acetate increased the frequency of micronuclei significantly and in concentration‐dependent manner; lavender oil did so only at the highest concentration tested, whereas linalool was devoid of genotoxicity. None of the tested substances led to an increase in nucleoplasmic bridges or nuclear buds frequency. These findings suggest that the mutagenic activity of lavender oil can be related to the presence of linalyl acetate, which seems to have a profile of an aneugenic agent. Environ. Mol. Mutagen. 52:69–71, 2011. © 2010 Wiley‐Liss, Inc.

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Metrics

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Citations

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References

Details

Published: Jan 01, 2011
Vol/Issue: 52(1)
Pages: 69-71
License: View

Authors

A

Antonella Di Sotto

Department of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, 00185 Rome, Italy

G

Gabriela Mazzanti

Department of Pharmacology of Natural Substances and General Physiology, University of Rome “La Sapienza,” Rome, Italy

Cite This Article

Antonella Di Sotto, Gabriela Mazzanti, Fabio Carbone, et al. (2011). Genotoxicity of lavender oil, linalyl acetate, and linalool on human lymphocytes in vitro. Environmental and Molecular Mutagenesis, 52(1), 69-71. https://doi.org/10.1002/em.20587

Genotoxicity of lavender oil, linalyl acetate, and linalool on human lymphocytes in vitro

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