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journal article Sep 27, 2016

Effects of occupational exposure to carbon black on peripheral white blood cell counts and lymphocyte subsets

Yufei Dai Huawei Duan Bryan A. Bassig Meng Ye ORCID Xiao Zhang ORCID Tao Meng ORCID Ping Bin Xiaowei Jia ORCID Meili Shen Rong Zhang ORCID Wei Hu ORCID Xiaofa Yang Roel Vermeulen ORCID Debra Silverman Nathaniel Rothman ORCID Qing Lan Shanfa Yu Yuxin Zheng
Environmental and Molecular Mutagenesis Vol. 57 No. 8 pp. 615-622 · Wiley
View at Publisher Save 10.1002/em.22036
Abstract
The International Agency for Research on Cancer has classified carbon black (CB) as a possible (Group 2B) human carcinogen. Given that most CB manufacturing processes result in the emission of various types of chemicals, it is uncertain if the adverse health effects that have been observed in CB‐exposed workers are related to CB specifically or are due to other exposures. To address this issue, we conducted a cross‐sectional molecular epidemiology study in China of 106 male factory workers who were occupationally exposed to pure CB and 112 unexposed male workers frequency‐matched by age and smoking status from the same geographic region. Repeated personal exposure measurements were taken in workers before biological sample collection. Peripheral blood from all workers was used for the complete blood cell count and lymphocyte subsets analysis. Compared to unexposed workers, eosinophil counts in workers exposed to CB were increased by 30.8% (P = 0.07) after adjusting for potential confounders. When stratified by smoking status, statistically significant differences in eosinophils between CB exposed and unexposed workers were only present among never smokers (P = 0.040). Smoking is associated with alterations in various cell counts; however, no significant interaction between CB exposure and smoking status for any cell counts was observed. Given that inflammation, characterized in part by elevated eosinophils in peripheral blood, may be associated with increased cancer risk, our findings provide new biologic insights into the potential relationship between CB exposure and lung carcinogenesis. Environ. Mol. Mutagen. 57:589–604, 2016. © 2016 Wiley Periodicals, Inc.
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Metrics
18
Citations
42
References
Details
Published
Sep 27, 2016
Vol/Issue
57(8)
Pages
615-622
License
View
Authors
Y
Yufei Dai

Key Laboratory National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention Beijing 100050 China; Occupational and Environmental Epidemiology Branch National Cancer Institute Rockville Maryland

H
Huawei Duan

Key Laboratory National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention Beijing 100050 China

B
Bryan A. Bassig

Occupational and Environmental Epidemiology Branch National Cancer Institute Rockville Maryland

M
Meng Ye

Key Laboratory National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention Beijing 100050 China

X
Xiao Zhang

Key Laboratory National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention Beijing 100050 China

T
Tao Meng

Key Laboratory National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention Beijing 100050 China

P
Ping Bin

Key Laboratory National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention Beijing 100050 China

X
Xiaowei Jia

Key Laboratory National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention Beijing 100050 China

M
Meili Shen

Key Laboratory National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention Beijing 100050 China

R
Rong Zhang

Key Laboratory National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention Beijing 100050 China; Department of Toxicology School of Public Health Hebei Medical University Shijiazhuang China

W
Wei Hu

Occupational and Environmental Epidemiology Branch National Cancer Institute Rockville Maryland

X
Xiaofa Yang

Jiao Zuo Center for Disease Control and Prevention Jiaozuo China

R
Roel Vermeulen

Division of Environmental Epidemiology Institute for Risk Assessment Sciences, Utrecht University Utrecht the Netherlands

D
Debra Silverman

Occupational and Environmental Epidemiology Branch National Cancer Institute Rockville Maryland

N
Nathaniel Rothman

Occupational and Environmental Epidemiology Branch National Cancer Institute Rockville Maryland

Q
Qing Lan

Occupational and Environmental Epidemiology Branch National Cancer Institute Rockville Maryland

S
Shanfa Yu

Henan Provincial Institute for Occupational Health Zhengzhou China

Y
Yuxin Zheng

Key Laboratory National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention Beijing 100050 China

Funding
National Natural Science Foundation of China Award: 81130050
Cite This Article
Yufei Dai, Huawei Duan, Bryan A. Bassig, et al. (2016). Effects of occupational exposure to carbon black on peripheral white blood cell counts and lymphocyte subsets. Environmental and Molecular Mutagenesis, 57(8), 615-622. https://doi.org/10.1002/em.22036
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