Lactobacillus salivarius and Lactobacillus gasseri supplementation reduces stress‐induced sugar craving in mice

Marion Nicol; Emilie Lahaye; Mouna El Mehdi; Jean‐Luc do Rego; Jean‐Claude do Rego; Sergueï O. Fetissov

doi:10.1002/erv.3004

journal article Open Access Jun 26, 2023

Lactobacillus salivarius and Lactobacillus gasseri supplementation reduces stress‐induced sugar craving in mice

Marion Nicol Emilie Lahaye Mouna El Mehdi Jean‐Luc do Rego Jean‐Claude do Rego Sergueï O. Fetissov

European Eating Disorders Review Vol. 32 No. 6 pp. 1041-1054 · Wiley

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Abstract

AbstractObjectiveIncreased intake of sweets or sugar craving may occur in response to chronic stress representing a risk factor for development of eating disorders and obesity. However, no safe treatment of stress‐induced sugar craving is available. In this study we analysed effects of two Lactobacillus strains on food and sucrose intake in mice before and during their exposure to a chronic mild stress (CMS).Research Methods & ProceduresC57Bl6 mice were gavaged daily for 27 days with a mix of L. salivarius (LS) LS7892 and L. gasseri (LG) LG6410 strains or with 0.9% NaCl as a control. Following 10 days of gavage, mice were individually placed into the Modular Phenotypic cages, and after 7 days of acclimation were exposed to a CMS model for 10 days. Food, water and 2% sucrose intakes as well as meal pattern were monitored. Anxiety and depressive‐like behaviour were analysed by standard tests.ResultsExposure of mice to CMS was accompanied by increased size of sucrose intake in the control group likely reflecting the stress‐induced sugar craving. A consistent, about 20% lower total sucrose intake, was observed in the Lactobacilli‐treated group during stress which was mainly due to a reduced number of intakes. Lactobacilli treatment also modified the meal pattern before and during the CMS, showing a decrease of meal number and an increase of meal size with a tendency of reduced total daily food intake. Mild anti‐depressive behavioural effects of the Lactobacilli mix were also present.ConclusionSupplementation of mice with LS LS7892 and LG LG6410 decreases sugar consumption suggesting a potential utility of these strains against stress‐induced sugar craving.

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Details

Published: Jun 26, 2023
Vol/Issue: 32(6)
Pages: 1041-1054
License: View

Authors

M

Marion Nicol

Regulatory Peptides ‐ Energy Metabolism and Motivated Behavior Team, Neuroendocrine Endocrine and Germinal Differentiation and Communication Laboratory Inserm UMR 1239 University of Rouen Normandie Rouen France

E

Emilie Lahaye

Regulatory Peptides ‐ Energy Metabolism and Motivated Behavior Team, Neuroendocrine Endocrine and Germinal Differentiation and Communication Laboratory Inserm UMR 1239 University of Rouen Normandie Rouen France

M

Mouna El Mehdi

Regulatory Peptides ‐ Energy Metabolism and Motivated Behavior Team, Neuroendocrine Endocrine and Germinal Differentiation and Communication Laboratory Inserm UMR 1239 University of Rouen Normandie Rouen France

J

Jean‐Luc do Rego

University of Rouen Normandie Inserm US51 CNRS UAR2026 Animal Behavioral Platform SCAC‐HeRacLeS Institute for Research and Innovation in Biomedicine (IRIB) Rouen France

J

Jean‐Claude do Rego

University of Rouen Normandie Inserm US51 CNRS UAR2026 Animal Behavioral Platform SCAC‐HeRacLeS Institute for Research and Innovation in Biomedicine (IRIB) Rouen France

S

Sergueï O. Fetissov

Regulatory Peptides ‐ Energy Metabolism and Motivated Behavior Team, Neuroendocrine Endocrine and Germinal Differentiation and Communication Laboratory Inserm UMR 1239 University of Rouen Normandie Rouen France

Cite This Article

Marion Nicol, Emilie Lahaye, Mouna El Mehdi, et al. (2023). Lactobacillus salivarius and Lactobacillus gasseri supplementation reduces stress‐induced sugar craving in mice. European Eating Disorders Review, 32(6), 1041-1054. https://doi.org/10.1002/erv.3004

Lactobacillus salivarius and Lactobacillus gasseri supplementation reduces stress‐induced sugar craving in mice

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