Evaluation of Published Bioconcentration Factor (BCF) and Bioaccumulation Factor (BAF) Data for Per- and Polyfluoroalkyl Substances Across Aquatic Species

Lawrence P. Burkhard

doi:10.1002/etc.5010

journal article Feb 19, 2021

Evaluation of Published Bioconcentration Factor (BCF) and Bioaccumulation Factor (BAF) Data for Per- and Polyfluoroalkyl Substances Across Aquatic Species

Lawrence P. Burkhard

Environmental Toxicology and Chemistry Vol. 40 No. 6 pp. 1530-1543 · Oxford University Press (OUP)

View at Publisher Save 10.1002/etc.5010

Abstract

Abstract
Per- and polyfluoroalkyl substances (PFAS) are a group of man-made chemicals of concern across the globe, and some of the PFAS chemicals are known to be bioaccumulative in aquatic species. A literature search for bioconcentration factors (BCFs) and bioaccumulation factors (BAFs) for PFAS has been done, and data for 22 taxonomic classes were assembled. The assembled data were evaluated for quality, and for gaps and limitations in bioaccumulation information for the PFAS universe of chemicals. In general, carbonyl and sulfonyl PFAS classes are relatively data rich, whereas phosphate, fluorotelomer, and ether PFAS classes are data limited for fish and nonexistent for most other taxonomic classes. Taxonomic classes with the most measurements were, in descending order, Teleostei (fish), Bivalvia, and Malacostraca. For fish, median whole-body log BAFs (L/kg wet wt) for perfluorooctane sulfonic acid and perfluorooctanoic acid were 3.55 (standard deviation [SD] = 0.83, n = 84) and 2.16 (SD = 0.85, n = 48) using all measurements, respectively. In comparison with freshwater species, data are limited for marine species, and further research is needed to determine whether the BAFs for freshwater and marine species should be the same or different. The BAFs for some PFAS appear to be consistent with the BCFs developed with laboratory experiments, in which values decline with increasing concentrations in water. Environ Toxicol Chem 2021;40:1530–1543. Published 2021. This article is a U.S. Government work and is in the public domain in the USA.

Topics

No keywords indexed for this article. Browse by subject →

References

68

[1]

Abercrombie "Larval amphibians rapidly bioaccumulate poly-and perfluoroalkyl substances" Ecotoxicol Environ Saf (2019) 10.1016/j.ecoenv.2019.04.022

[2]

Ahrens "Fate and effects of poly-and perfluoroalkyl substances in the aquatic environment: A review" Environ Toxicol Chem (2014) 10.1002/etc.2663

[3]

Ankley "Assessing the ecological risks of per-and polyfluoroalkyl substances: Current state-of-the science and a proposed path forward" Environ Toxicol Chem (2020) 10.1002/etc.4869

[4]

Armitage "Assessing the bioaccumulation potential of ionizable organic compounds: Current knowledge and research priorities" Environ Toxicol Chem (2017) 10.1002/etc.3680

[5]

Armitage "Assessing the bioaccumulation potential of ionizable organic compounds: Current knowledge and research priorities" Environ Toxicol Chem (2017) 10.1002/etc.3680

[6]

Arnot "A review of bioconcentration factor (BCF) and bioaccumulation factor (BAF) assessments for organic chemicals in aquatic organisms" Environ Rev (2006) 10.1139/a06-005

[7]

Babut "Per-and poly-fluoroalkyl compounds in freshwater fish from the Rhône River: Influence of fish size, diet, prey contamination and biotransformation" Sci Total Environ (2017) 10.1016/j.scitotenv.2017.06.111

[8]

Brooke (2004)

[9]

Perfluoroalkyl and polyfluoroalkyl substances in the environment: Terminology, classification, and origins

Robert C Buck, James Franklin, Urs Berger et al.

Integrated Environmental Assessment and Management 2011 10.1002/ieam.258

[10]

Casal "Accumulation of perfluoroalkylated substances in oceanic plankton" Environ Sci Technol (2017) 10.1021/acs.est.6b05821

[11]

Chen "Bioavailability and bioconcentration potential of perfluoroalkyl-phosphinic and-phosphonic acids in zebrafish (Danio rerio): Comparison to perfluorocarboxylates and perfluorosulfonates" Sci Total Environ (2016) 10.1016/j.scitotenv.2016.05.215

[12]

Chen "Occurrence, partitioning and bioaccumulation of emerging and legacy per-and polyfluoroalkyl substances in Taihu Lake, China" Sci Total Environ (2018) 10.1016/j.scitotenv.2018.03.301

[13]

Consoer "Toxicokinetics of perfluorooctanoate (PFOA) in rainbow trout (Oncorhynchus mykiss)" Aquat Toxicol (2014) 10.1016/j.aquatox.2014.07.022

[14]

Cui "Occurrence and tissue distribution of novel perfluoroether carboxylic and sulfonic acids and legacy per/polyfluoroalkyl substances in black-spotted frog (Pelophylax nigromaculatus)" Environ Sci Technol (2018) 10.1021/acs.est.7b03662

[15]

Dai "Bioaccumulation and uptake routes of perfluoroalkyl acids in Daphnia magna" Chemosphere (2013) 10.1016/j.chemosphere.2012.08.026

[16]

DeWitt (2015) 10.1007/978-3-319-15518-0

[17]

Essumang "Perfluoroalkyl acids (PFASs) in the Pra and Kakum River basins and associated tap water in Ghana" Sci Total Environ (2017) 10.1016/j.scitotenv.2016.11.035

[18]

Fang "Trophic magnification and isomer fractionation of perfluoroalkyl substances in the food web of Taihu Lake, China" Environ Sci Technol (2014) 10.1021/es405018b

[19]

Fernández-Sanjuan "Bioaccumulation and effects of perfluorinated compounds (PFCs) in zebra mussels (Dreissena polymorpha)" Environ Sci Pollut Res (2013) 10.1007/s11356-012-1158-8

[20]

Giesy "Global distribution of perfluorooctane sulfonate in wildlife" Environ Sci Technol (2001) 10.1021/es001834k

[21]

Giesy (2010)

[22]

Han "Renal elimination of perfluorocarboxylates (PFCAs)" Chem Res Toxicol (2012) 10.1021/tx200363w

[23]

Hloušková "Occurrence of brominated flame retardants and perfluoroalkyl substances in fish from the Czech aquatic ecosystem" Sci Total Environ (2013) 10.1016/j.scitotenv.2013.04.081

[24]

Hoke "Aquatic hazard, bioaccumulation and screening risk assessment for 6:2 fluorotelomer sulfonate" Chemosphere. (2015) 10.1016/j.chemosphere.2015.01.033

[25]

Houde "Biological monitoring of polyfluoroalkyl substances: A review" Environ Sci Technol (2006) 10.1021/es052580b

[26]

Houde "Fractionation and bioaccumulation of perfluorooctane sulfonate (PFOS) isomers in a Lake Ontario food web" Environ Sci Technol (2008) 10.1021/es800906r

[27]

Houde "Monitoring of perfluorinated compounds in aquatic biota: An updated review: PFCs in aquatic biota" Environ Sci Technol (2011) 10.1021/es104326w

[28]

Howard "Swift-review: A text-mining workbench for systematic review" Syst Rev (2016) 10.1186/s13643-016-0263-z

[29]

Inoue "Unique physicochemical properties of perfluorinated compounds and their bioconcentration in common carp Cyprinus carpio L" Arch Environ Contam Toxicol (2012) 10.1007/s00244-011-9730-7

[30]

Jeon "Bioconcentration of perfluorinated compounds in blackrock fish, Sebastes schlegeli, at different salinity levels" Environ Toxicol Chem (2010) 10.1002/etc.310

[31]

Jeon "Bioaccumulation of perfluorochemicals in Pacific oyster under different salinity gradients" Environ Sci Technol (2010) 10.1021/es100151r

[32]

Khazaee "Evaluating parameter availability for physiologically based pharmacokinetic (PBTK) modeling of perfluorooctanoic acid (PFOA) in zebrafish" Environ Sci Process Impact (2018) 10.1039/c7em00474e

[33]

Klimisch "A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data" Regul Toxicol Pharmacol (1997) 10.1006/rtph.1996.1076

[34]

Kwadijk "Distribution of perfluorinated compounds in aquatic systems in the Netherlands" Environ Sci Technol (2010) 10.1021/es100485e

[35]

Labadie "Partitioning behaviour of perfluorinated alkyl contaminants between water, sediment and fish in the Orge River (nearby Paris, France)" Environ Pollut (2011) 10.1016/j.envpol.2010.10.039

[36]

Larson "Modeling avian exposures to perfluoroalkyl substances in aquatic habitats impacted by historical aqueous film forming foam releases" Chemosphere (2018) 10.1016/j.chemosphere.2018.03.004

[37]

Liu "Novel perspectives on the bioaccumulation of PFCs—The concentration dependency" Environ Sci Technol (2011) 10.1021/es202078n

[38]

Loi "Trophic magnification of poly-and perfluorinated compounds in a subtropical food web" Environ Sci Technol (2011) 10.1021/es200432n

[39]

Lorenzo "Perfluoroalkyl substances in the Ebro and Guadalquivir River basins (Spain)" Sci Total Environ (2016) 10.1016/j.scitotenv.2015.07.045

[40]

Martin "Bioconcentration and tissue distribution of perfluorinated acids in rainbow trout (Oncorhynchus mykiss)" Environ Toxicol Chem (2003) 10.1897/1551-5028(2003)022<0196:batdop>2.0.co;2

[41]

Martin "Dietary accumulation of perfluorinated acids in juvenile rainbow trout (Oncorhynchus mykiss)" Environ Toxicol Chem (2003) 10.1897/1551-5028(2003)022<0189:daopai>2.0.co;2

[42]

Martin "Perfluoroalkyl contaminants in a food web from Lake Ontario" Environ Sci Technol (2004) 10.1021/es049331s

[43]

McCarthy "Ecological considerations of per-and polyfluoroalkyl substances (PFAS)" Curr Pollut Rep (2017) 10.1007/s40726-017-0070-8

[44]

Mittal "Formation of PFAAs in fish through biotransformation: A PBTK approach" Chemosphere (2018) 10.1016/j.chemosphere.2018.03.064

[45]

Munoz "Evidence for the trophic transfer of perfluoroalkylated substances in a temperate macrotidal estuary" Environ Sci Technol (2017) 10.1021/acs.est.7b02399

[46]

Ng "Bioaccumulation of perfluorinated alkyl acids: Observations and models" Environ Sci Technol (2014) 10.1021/es404008g

[47]

Organisation for Economic Co-operation and Development (2006)

[48]

Organisation for Economic Co-operation and Development (2008)

[49]

Organisation for Economic Co-operation and Development (2012)

[50]

Organisation for Economic Co-operation and Development (2015)

Showing 50 of 68 references

Cited By

206

Environmental Occurrence and Biotic Concentrations of Ultrashort-Chain Perfluoroalkyl Acids: Overlooked Global Organofluorine Contaminants

Yue Zhi, XIONGWEI LU · 2024

Environmental Science & Technol...

Metrics

206

Citations

68

References

Details

Published: Feb 19, 2021
Vol/Issue: 40(6)
Pages: 1530-1543
License: View

Authors

L

Lawrence P. Burkhard

Great Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Exposure, Office of Research and Development US Environmental Protection Agency Duluth Minnesota USA

Cite This Article

Lawrence P. Burkhard (2021). Evaluation of Published Bioconcentration Factor (BCF) and Bioaccumulation Factor (BAF) Data for Per- and Polyfluoroalkyl Substances Across Aquatic Species. Environmental Toxicology and Chemistry, 40(6), 1530-1543. https://doi.org/10.1002/etc.5010

Evaluation of Published Bioconcentration Factor (BCF) and Bioaccumulation Factor (BAF) Data for Per- and Polyfluoroalkyl Substances Across Aquatic Species

You May Also Like