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journal article Sep 02, 2013

The diverse role of miR‐31 in regulating cancer associated phenotypes

Eeva M. Laurila Anne Kallioniemi
Genes, Chromosomes and Cancer Vol. 52 No. 12 pp. 1103-1113 · Wiley
View at Publisher Save 10.1002/gcc.22107
Abstract
In the past 10 years research on miRNAs has demonstrated their central role in regulating gene expression both in normal and diseased tissue. The expression of miRNAs is widely altered in cancer, leading to abnormal expression of the genes regulated by these miRNAs, and subsequently alterations in entire molecular networks and pathways. One especially interesting cancer‐related miRNA is miR‐31 which is frequently altered in a large variety of cancers. The functional role of miR‐31 is extremely complex and miR‐31 can hold both tumor suppressive and oncogenic roles in different tumor types. The phenotype caused by aberrant miR‐31 expression seems to be strongly dependent on the endogenous expression levels. For example, in breast cancer loss of miR‐31 expression is associated with high risk of metastases, whereas in colorectal cancer high miR‐31 expression correlates with advanced disease stage. This review summarizes the complex expression patterns of miR‐31 in human cancers, describes the variable phenotypes caused by altered miR‐31 expression, and highlights the current knowledge on the genes targeted by miR‐31. © 2013 Wiley Periodicals, Inc.
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Showing 50 of 70 references

Metrics
78
Citations
70
References
Details
Published
Sep 02, 2013
Vol/Issue
52(12)
Pages
1103-1113
License
View
Authors
E
Eeva M. Laurila

Institute of Biomedical Technology University of Tampere and BioMediTech Tampere Finland

A
Anne Kallioniemi

Institute of Biomedical Technology University of Tampere and BioMediTech Tampere Finland; Fimlab Laboratories Tampere Finland

Cite This Article
Eeva M. Laurila, Anne Kallioniemi (2013). The diverse role of miR‐31 in regulating cancer associated phenotypes. Genes, Chromosomes and Cancer, 52(12), 1103-1113. https://doi.org/10.1002/gcc.22107
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