Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: An fMRI study

Serge A.R.B. Rombouts; Frederik Barkhof; Rutger Goekoop; Cornelis J. Stam; Philip Scheltens

doi:10.1002/hbm.20160

journal article Jun 13, 2005

Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: An fMRI study

Serge A.R.B. Rombouts Frederik Barkhof Rutger Goekoop Cornelis J. Stam Philip Scheltens

Human Brain Mapping Vol. 26 No. 4 pp. 231-239 · Wiley

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Abstract

AbstractActivity and reactivity of the default mode network in the brain was studied using functional magnetic resonance imaging (fMRI) in 28 nondemented individuals with mild cognitive impairment (MCI), 18 patients with mild Alzheimer's disease (AD), and 41 healthy elderly controls (HC). The default mode network was interrogated by means of decreases in brain activity, termed deactivations, during a visual encoding task and during a nonspatial working memory task. Deactivation was found in the default mode network involving the anterior frontal, precuneus, and posterior cingulate cortex. MCI patients showed less deactivation than HC, but more than AD. The most pronounced differences between MCI, HC, and AD occurred in the very early phase of deactivation, reflecting the reactivity and adaptation of the network. The default mode network response in the anterior frontal cortex significantly distinguished MCI from both HC (in the medial frontal) and AD (in the anterior cingulate cortex). The response in the precuneus could only distinguish between patients and HC, not between MCI and AD. These findings may be consistent with the notion that MCI is a transitional state between healthy aging and dementia and with the proposed early changes in MCI in the posterior cingulate cortex and precuneus. These findings suggest that altered activity in the default mode network may act as an early marker for AD pathology. Hum Brain Mapp, 2005. © 2005 Wiley‐Liss, Inc.

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Details

Published: Jun 13, 2005
Vol/Issue: 26(4)
Pages: 231-239
License: View

Authors

S

Serge A.R.B. Rombouts

F

Frederik Barkhof

From the Department of Radiology and Nuclear Medicine (F.B.), Amsterdam University Medical Center, VU Medical Center, Amsterdam, Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, UK; Department of Neurology (D.S.K.) and Mayo Clinic Alzheimer Research Center, Mayo Clinic, Rochester MN.

Cite This Article

Serge A.R.B. Rombouts, Frederik Barkhof, Rutger Goekoop, et al. (2005). Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: An fMRI study. Human Brain Mapping, 26(4), 231-239. https://doi.org/10.1002/hbm.20160

Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: An fMRI study

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