The relationship between resting‐state amplitude fluctuations and memory‐related deactivations of the default mode network in young and older adults

Jasmin M. Kizilirmak; Joram Soch; Hartmut Schütze; Emrah Düzel; Hannah Feldhoff; Larissa Fischer; Lea Knopf; Anne Maass; Matthias Raschick; Annika Schult; Renat Yakupov; Anni Richter; Björn H. Schott

doi:10.1002/hbm.26299

journal article Open Access Apr 13, 2023

The relationship between resting‐state amplitude fluctuations and memory‐related deactivations of the default mode network in young and older adults

Jasmin M. Kizilirmak

Joram Soch

Hartmut Schütze Emrah Düzel

Hannah Feldhoff Larissa Fischer Lea Knopf Anne Maass

Matthias Raschick Annika Schult Renat Yakupov

Anni Richter

Björn H. Schott

Human Brain Mapping Vol. 44 No. 9 pp. 3586-3609 · Wiley

View at Publisher Save 10.1002/hbm.26299

Abstract

AbstractThe default mode network (DMN) typically exhibits deactivations during demanding tasks compared to periods of relative rest. In functional magnetic resonance imaging (fMRI) studies of episodic memory encoding, increased activity in DMN regions even predicts later forgetting in young healthy adults. This association is attenuated in older adults and, in some instances, increased DMN activity even predicts remembering rather than forgetting. It is yet unclear whether this phenomenon is due to a compensatory mechanism, such as self‐referential or schema‐dependent encoding, or whether it reflects overall reduced DMN activity modulation in older age. We approached this question by systematically comparing DMN activity during successful encoding and tonic, task‐independent, DMN activity at rest in a sample of 106 young (18–35 years) and 111 older (60–80 years) healthy participants. Using voxel‐wise multimodal analyses, we assessed the age‐dependent relationship between DMN resting‐state amplitude (mean percent amplitude of fluctuation, mPerAF) and DMN fMRI signals related to successful memory encoding, as well as their modulation by age‐related hippocampal volume loss, while controlling for regional grey matter volume. Older adults showed lower resting‐state DMN amplitudes and lower task‐related deactivations. However, a negative relationship between resting‐state mPerAF and subsequent memory effect within the precuneus was observed only in young, but not older adults. Hippocampal volumes showed no relationship with the DMN subsequent memory effect or mPerAF. Lastly, older adults with higher mPerAF in the DMN at rest tend to show higher memory performance, pointing towards the importance of a maintained ability to modulate DMN activity in old age.

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Details

Published: Apr 13, 2023
Vol/Issue: 44(9)
Pages: 3586-3609
License: View

Authors

J

Jasmin M. Kizilirmak

Cognitive Geriatric Psychiatry German Center for Neurodegenerative Diseases Göttingen Germany; Neurodidactics and NeuroLab Institute for Psychology, University of Hildesheim Hildesheim Germany; German Centre for Higher Education Research and Science Studies Hannover Germany

J

Joram Soch

Cognitive Geriatric Psychiatry German Center for Neurodegenerative Diseases Göttingen Germany; Bernstein Center for Computational Neuroscience Berlin Germany

H

Hartmut Schütze

Medical Faculty, Institute for Cognitive Neurology and Dementia Research Otto‐von‐Guericke‐University Magdeburg Germany; Center for Behavioral Brain Sciences Magdeburg Germany

E

Emrah Düzel

Medical Faculty, Institute for Cognitive Neurology and Dementia Research Otto‐von‐Guericke‐University Magdeburg Germany; Center for Behavioral Brain Sciences Magdeburg Germany; German Center for Neurodegenerative Diseases Magdeburg Germany

H

Hannah Feldhoff