Relevance of the primary lesion in the prognosis of metastatic cutaneous squamous cell carcinoma

Sydney Ch'ng; Jonathan R. Clark; Markus Brunner; Carsten E. Palme; Gary J. Morgan; Michael J. Veness

doi:10.1002/hed.22941

journal article Mar 16, 2012

Relevance of the primary lesion in the prognosis of metastatic cutaneous squamous cell carcinoma

Sydney Ch'ng Jonathan R. Clark Markus Brunner

Carsten E. Palme Gary J. Morgan Michael J. Veness

Head & Neck Vol. 35 No. 2 pp. 190-194 · Wiley

View at Publisher Save 10.1002/hed.22941

Abstract

AbstractBackgroundIt remains unclear how primary tumor factors impact on prognosis in patients with nodal metastasis in head and neck cutaneous squamous cell carcinoma (SCC). The purpose of this study was to assess whether primary tumor characteristics are independent prognostic factors.MethodsPatients treated for metastatic cutaneous SCC from 1978 to 2010 were identified (n = 239). A proportional hazards model was used to assess the effect of primary tumor variables.ResultsOn multivariable analysis, tumor differentiation (hazard ratio [HR], 0.2; 95% confidence interval [CI], 0.1–0.8; p = .03) was found to be significantly associated with disease‐specific survival (DSS), unlike margin status (p = .23), tumor size (p = .21), and thickness (p = .11). Patient, treatment, and nodal factors were confirmed to be important predictors of survival.ConclusionThis article suggests that pathological features of the primary lesion bear little importance in the presence of established nodal metastasis, other than tumor differentiation. It validates the grouping of T1–3N1 as stage III under the current American Joint Committee on Cancer (AJCC) TNM staging system. © 2012 Wiley Periodicals, Inc. Head Neck, 2013

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Metrics

35

Citations

15

References

Details

Published: Mar 16, 2012
Vol/Issue: 35(2)
Pages: 190-194
License: View

Authors

From the Faculty of Medicine and the Central Clinical School, University of Sydney; Department of Head and Neck Surgery and Sydney Facial Nerve Service, The Chris O’Brien Lifehouse; the Illawarra Health and Medical Research Institute; and the Centre for Oncology Education and Research Translation.

Cite This Article

Sydney Ch'ng, Jonathan R. Clark, Markus Brunner, et al. (2012). Relevance of the primary lesion in the prognosis of metastatic cutaneous squamous cell carcinoma. Head & Neck, 35(2), 190-194. https://doi.org/10.1002/hed.22941

Relevance of the primary lesion in the prognosis of metastatic cutaneous squamous cell carcinoma

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