BishtRef
Articles Journals Publishers Authors Subjects Most Cited New Papers Year Stats Open Access
journal article Dec 23, 2015

Surgical management of oropharyngeal squamous cell carcinoma: Survival and functional outcomes

Bhavna Kumar ORCID Michael J. Cipolla Matthew O. Old Nicole V. Brown Stephen Y. Kang Peter T. Dziegielewski ORCID Kasim Durmus Enver Ozer Amit Agrawal ORCID Ricardo L. Carrau David E. Schuller Marino E. Leon Quintin Pan ORCID Pawan Kumar ORCID Valerie Wood ORCID Jessica Burgers Paul E. Wakely Theodoros N. Teknos
Head & Neck Vol. 38 No. S1 · Wiley
View at Publisher Save 10.1002/hed.24319
Abstract
AbstractBackgroundThe purpose of this study was to further define the impact of primary surgery in the management of oropharyngeal squamous cell carcinoma (SCC).MethodsTwo hundred ninety‐six patients with oropharyngeal SCC treated with primary surgery were included. Multivariable analysis and recursive partitioning analysis (RPA) identified predictors of survival and gastrostomy tube presence.ResultsMultivariable analysis identified that HPV negativity (p = .0002), presence of extranodal extension (p = .0025), and advanced T classification (p = .0081) were independent predictors of survival. For HPV‐positive patients, surgical approach (p = .0111) and margin status (p = .0287) were significant predictors of survival. For HPV‐negative patients, extranodal extension (p = .0021) and advanced T classification (p = .0342) were significant predictors of survival. Smoking status and advanced neck disease did not impact survival, and the addition of adjuvant chemotherapy did not confer survival benefit in HPV‐positive or HPV‐negative subgroups.ConclusionIndependent predictors of survival are unique in patients with oropharyngeal SCC treated with primary surgery. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1794–E1802, 2016
Topics

No keywords indexed for this article. Browse by subject →

References
41
[15]
Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer

K. Kian Ang, Jonathan Harris, Richard Wheeler et al.

New England Journal of Medicine 10.1056/nejmoa0912217
[33]
NCCN Clinical Practice Guidelines in Oncology. Head and Neck Cancers version 2.2014. Available at:http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed May 1 2015.
[39]
The R project for statistical computing. R: a language and environment for statistical computing. Available at:http://www.R‐project.org/. Accessed May 1 2015.
[40]
TherneauT AtkinsonB RipleyB.Rpart: recursive partitioning and regression trees. R package version 4.1‐8. Available at:https://cran.r‐project.org/web/packages/rpart/rpart.pdf. Accessed May 1 2015.
Metrics
43
Citations
41
References
Details
Published
Dec 23, 2015
Vol/Issue
38(S1)
License
View
Authors
B
Bhavna Kumar

Department of Otolaryngology – Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio

M
Michael J. Cipolla

Department of Otolaryngology – Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio

M
Matthew O. Old

Department of Otolaryngology – Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio

N
Nicole V. Brown

Department of Otolaryngology – Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio

S
Stephen Y. Kang

Department of Otolaryngology – Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio

P
Peter T. Dziegielewski

Department of Otolaryngology – Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio

K
Kasim Durmus

Department of Otolaryngology – Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio

E
Enver Ozer

Department of Otolaryngology – Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio

A
Amit Agrawal

Department of Otolaryngology – Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio

R
Ricardo L. Carrau

Department of Otolaryngology – Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio

D
David E. Schuller

Department of Otolaryngology – Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio

M
Marino E. Leon

Department of Otolaryngology – Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio

Q
Quintin Pan

Department of Otolaryngology – Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio

P
Pawan Kumar

Department of Otolaryngology – Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio

V
Valerie Wood

Department of Otolaryngology – Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio

J
Jessica Burgers

Department of Otolaryngology – Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio

P
Paul E. Wakely

Department of Otolaryngology – Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio

T
Theodoros N. Teknos

Department of Otolaryngology – Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute The Ohio State University Wexner Medical Center Columbus Ohio

Funding
This work was supported by The Ohio State University Comprehensive Cancer Center funds
Cite This Article
Bhavna Kumar, Michael J. Cipolla, Matthew O. Old, et al. (2015). Surgical management of oropharyngeal squamous cell carcinoma: Survival and functional outcomes. Head & Neck, 38(S1). https://doi.org/10.1002/hed.24319
Related

You May Also Like

Defining risk levels in locally advanced head and neck cancers: A comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501)

Jacques Bernier, Jay S. Cooper · 2005

1,521 citations

The addition of mood and anxiety domains to the University of Washington quality of life scale

Simon N. Rogers, Suzanne Gwanne · 2002

358 citations

Prognostic factors of clinically stage I and II oral tongue carcinoma—A comparative study of stage, thickness, shape, growth pattern, invasive front malignancy grading, martinez‐gimeno score, and pathologic features

Anthony Po Wing Yuen, King Yin Lam · 2002

287 citations

p16 expression as a surrogate marker for HPV‐related oropharyngeal carcinoma: A guide for interpretative relevance and consistency

Adel K. El‐Naggar, William H. Westra · 2011

262 citations

Vascularized bone flaps versus nonvascularized bone grafts for mandibular reconstruction: An outcome analysis of primary bony union and endosseous implant success

Robert D. Foster, James P. Anthony · 1999

260 citations