Prognostic value of C‐reactive protein/albumin ratio for patients with hypopharyngeal and laryngeal cancer undergoing invasive surgery involving laryngectomy

Akihito Kuboki; Hiroaki Kanaya; Tsuguhisa Nakayama; Wataru Konno; Kazutaka Goto; Itsuo Nakajima; Takashi Kashiwagi; Hideki Hirabayashi; Shin‐ichi Haruna

doi:10.1002/hed.25565

journal article Dec 15, 2018

Prognostic value of C‐reactive protein/albumin ratio for patients with hypopharyngeal and laryngeal cancer undergoing invasive surgery involving laryngectomy

Hiroaki Kanaya Tsuguhisa Nakayama Wataru Konno Kazutaka Goto Itsuo Nakajima Takashi Kashiwagi Hideki Hirabayashi Shin‐ichi Haruna

Head & Neck Vol. 41 No. 5 pp. 1342-1350 · Wiley

View at Publisher Save 10.1002/hed.25565

Abstract

AbstractBackgroundThe C‐reactive protein/albumin (CRP/Alb) ratio has been recently established as a prognostic indicator in various cancer types. However, few reports regarding the prognostic value of the CRP/Alb ratio in head and neck cancer exist. This study aimed to investigate the significance of the CRP/Alb ratio in clinical outcomes after invasive surgery involving laryngectomy for hypopharyngeal and laryngeal cancer.MethodsWe evaluated 56 patients who underwent total laryngectomy or total pharyngolaryngectomy between 2003 and 2012. Univariate and multivariate analyses were retrospectively performed to examine the prognostic value of the CRP/Alb ratio in these patients.ResultsThe optimal cutoff value of the CRP/Alb ratio was 0.32. Multivariate analysis showed that the CRP/Alb ratio was a significant and independent predictor of poor overall and disease‐free survival.ConclusionThe CRP/Alb ratio may be a novel and useful indicator for predicting postoperative outcomes in patients with hypopharyngeal and laryngeal cancer.

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Details

Published: Dec 15, 2018
Vol/Issue: 41(5)
Pages: 1342-1350
License: View

Authors

A

Akihito Kuboki

Department of Otorhinolaryngology‐Head and Neck Surgery Dokkyo Medical University Tochigi Japan; Department of Otolaryngology The Jikei University School of Medicine Tokyo Japan

H

Hiroaki Kanaya