The role of matrix stiffness in regulating cell behavior†

Rebecca G. Wells

doi:10.1002/hep.22193

journal article Apr 01, 2008

The role of matrix stiffness in regulating cell behavior†

Rebecca G. Wells

Hepatology Vol. 47 No. 4 pp. 1394-1400 · Ovid Technologies (Wolters Kluwer Health)

View at Publisher Save 10.1002/hep.22193

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References

49

[1]

Tissue Cells Feel and Respond to the Stiffness of Their Substrate

Dennis E. Discher, Paul Janmey, Yu-li Wang

Science 2005 10.1126/science.1116995

[2]

Storm "Nonlinear elasticity in biological gels" Nature (2005) 10.1038/nature03521

[3]

Levental "Soft biological materials and their impact on cell function" Soft Matter (2007) 10.1039/b610522j

[4]

Georges "Matrices with compliance comparable to that of brain tissue select neuronal over glial growth in mixed cortical cultures" Biophys J (2006) 10.1529/biophysj.105.073114

[5]

Myotubes differentiate optimally on substrates with tissue-like stiffness

Adam J. Engler, Maureen A. Griffin, Shamik Sen et al.

The Journal of cell biology 2004 10.1083/jcb.200405004

[6]

Georges "Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis" Am J Physiol Gastrointest Liver Physiol (2007) 10.1152/ajpgi.00032.2007

[7]

Yin "Assessment of hepatic fibrosis with magnetic resonance elastography" Clin Gastroenterol Hepatol (2007) 10.1016/j.cgh.2007.06.012

[8]

Hansen "Regulation of hepatocyte cell cycle progression and differentiation by type I collagen structure" Curr Top Dev Biol (2006) 10.1016/s0070-2153(05)72004-4

[9]

McDaniel "The stiffness of collagen fibrils influences vascular smooth muscle cell phenotype" Biophys J (2007) 10.1529/biophysj.106.089003

[10]

Pelham "Cell locomotion and focal adhesions are regulated by substrate flexibility" Proc Natl Acad Sci U S A (1997) 10.1073/pnas.94.25.13661

[11]

Cell type-specific response to growth on soft materials

Penelope C. Georges, Paul A. Janmey

Journal of Applied Physiology 2005 10.1152/japplphysiol.01121.2004

[12]

Kandow "Polyacrylamide hydrogels for cell mechanics: steps toward optimization and alternative uses" Methods Cell Biol (2007) 10.1016/s0091-679x(07)83002-0

[13]

Wakatsuki "Cell mechanics studied by a reconstituted model tissue" Biophys J (2000) 10.1016/s0006-3495(00)76481-2

[14]

Yeung "Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion" Cell Motil Cytoskeleton (2005) 10.1002/cm.20041

[15]

Nelson "Emergent patterns of growth controlled by multicellular form and mechanics" Proc Natl Acad Sci U S A (2005) 10.1073/pnas.0502575102

[16]

Desmouliere "Extracellular matrix deposition, lysyl oxidase expression, and myofibroblastic differentiation during the initial stages of cholestatic fibrosis in the rat" Lab Invest (1997)

[17]

Elbjeirami "Enhancing mechanical properties of tissue‐engineered constructs via lysyl oxidase crosslinking activity" J Biomed Mater Res A (2003) 10.1002/jbm.a.10021

[18]

Bruel "Inhibition of cross‐links in collagen is associated with reduced stiffness of the aorta in young rats" Atherosclerosis (1998) 10.1016/s0021-9150(98)00130-0

[19]

Brenner "New aspects of hepatic fibrosis" J Hepatol (2000) 10.1016/s0168-8278(00)80413-4

[20]

Issa "Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross‐linking" Gastroenterology (2004) 10.1053/j.gastro.2004.03.009

[21]

Griffith "Capturing complex 3D tissue physiology in vitro" Nat Rev Mol Cell Biol (2006) 10.1038/nrm1858

[22]

Gressner "Activation of proteoglycan synthesis in injured liver: a brief review of molecular and cellular aspects" Eur J Clin Chem Clin Biochem (1994)

[23]

Bershadsky "Adhesion‐mediated mechanosensitivity: a time to experiment, and a time to theorize" Curr Opin Cell Biol (2006) 10.1016/j.ceb.2006.08.012

[24]

Ingber "Cellular mechanotransduction: putting all the pieces together again" FASEB J (2006) 10.1096/fj.05-5424rev

[25]

Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment

Rowena McBeath, Dana M Pirone, Celeste M Nelson et al.

Developmental Cell 2004 10.1016/s1534-5807(04)00075-9

[26]

Tomasek "Myofibroblasts and mechano‐regulation of connective tissue remodelling" Nat Rev Mol Cell Biol (2002) 10.1038/nrm809

[27]

Li "Transforming growth factor‐beta and substrate stiffness regulate portal fibroblast activation in culture" HEPATOLOGY (2007) 10.1002/hep.21792

[28]

Semler "Mechanochemical manipulation of hepatocyte aggregation can selectively induce or repress liver‐specific function" Biotechnol Bioeng (2000) 10.1002/1097-0290(20000820)69:4<359::aid-bit2>3.0.co;2-q

[29]

Paszek "Tensional homeostasis and the malignant phenotype" Cancer Cell (2005) 10.1016/j.ccr.2005.08.010

[30]

Wang "Substrate flexibility regulates growth and apoptosis of normal but not transformed cells" Am J Physiol Cell Physiol (2000) 10.1152/ajpcell.2000.279.5.c1345

[31]

Arora "The compliance of collagen gels regulates transforming growth factor‐beta induction of alpha‐smooth muscle actin in fibroblasts" Am J Pathol (1999) 10.1016/s0002-9440(10)65334-5

[32]

Bischofs "Cell organization in soft media due to active mechanosensing" Proc Natl Acad Sci U S A (2003) 10.1073/pnas.1233544100

[33]

Cell Movement Is Guided by the Rigidity of the Substrate

Chun-Min Lo, Hong-Bei Wang, Micah Dembo et al.

Biophysical Journal 2000 10.1016/s0006-3495(00)76279-5

[34]

Flanagan "Neurite branching on deformable substrates" Neuroreport (2002) 10.1097/00001756-200212200-00007

[35]

Sieminski "The relative magnitudes of endothelial force generation and matrix stiffness modulate capillary morphogenesis in vitro" Exp Cell Res (2004) 10.1016/j.yexcr.2004.03.035

[36]

Yamamura "Effects of the mechanical properties of collagen gel on the in vitro formation of microvessel networks by endothelial cells" Tissue Eng (2007) 10.1089/ten.2006.0333

[37]

Fassett "Type I collagen structure regulates cell morphology and EGF signaling in primary rat hepatocytes through cAMP‐dependent protein kinase A" Mol Biol Cell (2006) 10.1091/mbc.e05-09-0871

[38]

Semler "Engineering hepatocellular morphogenesis and function via ligand‐presenting hydrogels with graded mechanical compliance" Biotechnol Bioeng (2005) 10.1002/bit.20328

[39]

Friedman "Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix" J Biol Chem (1989) 10.1016/s0021-9258(18)81686-6

[40]

Gaca "Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase‐activated receptors" J Hepatol (2002) 10.1016/s0168-8278(01)00285-9

[41]

McGuire "Role of extracellular matrix in regulating fenestrations of sinusoidal endothelial cells isolated from normal rat liver" HEPATOLOGY (1992) 10.1002/hep.1840150603

[42]

Clouzeau‐Girard "Effects of bile acids on biliary epithelial cell proliferation and portal fibroblast activation using rat liver slices" Lab Invest (2006) 10.1038/labinvest.3700386

[43]

Guyot "The common bile duct ligation in rat: A relevant in vivo model to study the role of mechanical stress on cell and matrix behaviour" Histochem Cell Biol (2006) 10.1007/s00418-006-0185-2

[44]

Iwamoto "Inhibition of integrin signaling with Arg‐Gly‐Asp motifs in rat hepatic stellate cells" J Hepatol (1998) 10.1016/s0168-8278(98)80256-0

[45]

Shafiei "The role of integrin‐linked kinase in liver wound healing" J Biol Chem (2006) 10.1074/jbc.m513544200

[46]

Zhang "Involvement of integrin‐linked kinase in carbon tetrachloride‐induced hepatic fibrosis in rats" HEPATOLOGY (2006) 10.1002/hep.21315

[47]

Yee "Rho directs activation‐associated changes in rat hepatic stellate cell morphology via regulation of the actin cytoskeleton" HEPATOLOGY (1998) 10.1002/hep.510280336

[48]

Foucher "Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study" Gut (2006) 10.1136/gut.2005.069153

[49]

Yin "Quantitative assessment of hepatic fibrosis in an animal model with magnetic resonance elastography" Magn Reson Med (2007) 10.1002/mrm.21286

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