Hypoxia and Hypoxia Inducible Factors: Diverse Roles in Liver Diseases

Bharath Nath; Gyongyi Szabo

doi:10.1002/hep.25497

journal article Feb 01, 2012

Hypoxia and Hypoxia Inducible Factors: Diverse Roles in Liver Diseases

Bharath Nath Gyongyi Szabo

Hepatology Vol. 55 No. 2 pp. 622-633 · Ovid Technologies (Wolters Kluwer Health)

View at Publisher Save 10.1002/hep.25497

Abstract

Abstract

Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The hypoxia inducible factors (HIFs) are a family of evolutionarily conserved transcriptional regulators that affect a homeostatic response to low oxygen tension and have been identified as key mediators of angiogenesis, inflammation, and metabolism. In this review we summarize the evidence for a role of HIFs across a range of hepatic pathophysiology. We describe regulation of the HIFs and review investigations that demonstrate a role for HIFs in the development of liver fibrosis, activation of innate immune pathways, hepatocellular carcinoma, as well as other liver diseases in both human disease as well as murine models. (Hepatology 2012;)

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Details

Published: Feb 01, 2012
Vol/Issue: 55(2)
Pages: 622-633
License: View

Authors

Cite This Article

Bharath Nath, Gyongyi Szabo (2012). Hypoxia and Hypoxia Inducible Factors: Diverse Roles in Liver Diseases. Hepatology, 55(2), 622-633. https://doi.org/10.1002/hep.25497

Hypoxia and Hypoxia Inducible Factors: Diverse Roles in Liver Diseases

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