Elevated oxidative stress and DNA damage and repair levels in urinary bladder carcinomas associated with schistosomiasis

Elsayed I. Salim; Keiichirou Morimura; Ahmed Menesi; Mohammed El‐Lity; Shoji Fukushima; Hideki Wanibuchi

doi:10.1002/ijc.23547

journal article May 28, 2008

Elevated oxidative stress and DNA damage and repair levels in urinary bladder carcinomas associated with schistosomiasis

Elsayed I. Salim Keiichirou Morimura Ahmed Menesi Mohammed El‐Lity Shoji Fukushima Hideki Wanibuchi

International Journal of Cancer Vol. 123 No. 3 pp. 601-608 · Wiley

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Abstract

AbstractTo cast light on mechanisms underlying development of urothelial carcinomas (UCs) of the urinary bladder associated with Schistosomiasis, we immunohistochemically analyzed the relationship between oxidative stress markers, DNA single strand breaks (ssDNA) which could also measure the levels of base damage and apoptosis in DNA, and expression of DNA repair genes with levels of nitric oxide synthases in bladder carcinomas of Egyptian patients with or without Schistosoma hematobium infection. Marked elevation of 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) levels was found in squamous cell carcinomas and UCs associated with Schistosomiasis when compared with non‐Schistosomal carcinomas. This was accompanied by strong over expression of the DNA‐repair genes, 8‐oxoguanine‐DNA‐glycosylase and apurinic/apyrimidinic endonuclease, as well as increased formation levels of ssDNA. Expression levels of inducible nitric oxide synthase (iNOS) which is known to be indirectly related to oxidative stress was higher in Schistosomal than in the non‐Schistosomal carcinomas. However, expression of endothelial nitric oxide synthase was slightly stronger in non‐Schistosomal than in the Schistosomal carcinomas. In conclusion, these findings suggest a strong correlation between Schistosoma haematobium infection and increased levels of oxidative stress accompanied by a continuous DNA damage and repair in UCs, all directly correlating with elevated iNOS. © 2008 Wiley‐Liss, Inc.

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Details

Published: May 28, 2008
Vol/Issue: 123(3)
Pages: 601-608
License: View

Authors

Funding

Ministry of Education, Culture, Sports, Science and Technology (Grant-in-aid for Scientific Research), Japan

Cite This Article

Elsayed I. Salim, Keiichirou Morimura, Ahmed Menesi, et al. (2008). Elevated oxidative stress and DNA damage and repair levels in urinary bladder carcinomas associated with schistosomiasis. International Journal of Cancer, 123(3), 601-608. https://doi.org/10.1002/ijc.23547

Elevated oxidative stress and DNA damage and repair levels in urinary bladder carcinomas associated with schistosomiasis

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