Lung carcinogenesis by tobacco smoke

Stephen S. Hecht

doi:10.1002/ijc.27816

journal article Oct 03, 2012

Lung carcinogenesis by tobacco smoke

Stephen S. Hecht

International Journal of Cancer Vol. 131 No. 12 pp. 2724-2732 · Wiley

View at Publisher Save 10.1002/ijc.27816

Abstract

AbstractCigarette smoke is a complex mixture of chemicals including multiple genotoxic lung carcinogens. The classic mechanisms of carcinogen metabolic activation to DNA adducts, leading to miscoding and mutations in critical growth control genes, applies to this mixture but some aspects are difficult to establish because of the complexity of the exposure. This article discusses certain features of this mechanism including the role of nicotine and its receptors; lung carcinogens, co‐carcinogens and related substances in cigarette smoke; structurally characterized DNA adducts in the lungs of smokers; the mutational consequences of DNA adduct formation in smokers' lungs; and biomarkers of nicotine and carcinogen uptake as related to lung cancer. While there are still uncertainties which may never be fully resolved, the general mechanisms by which cigarette smoking causes lung cancer are well understood and provide insights relevant to prevention of lung cancer, the number one cancer killer in the world, causing 1.37 million deaths per year.

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Metrics

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Citations

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References

Details

Published: Oct 03, 2012
Vol/Issue: 131(12)
Pages: 2724-2732
License: View

Authors

S

Stephen S. Hecht

Cite This Article

Stephen S. Hecht (2012). Lung carcinogenesis by tobacco smoke. International Journal of Cancer, 131(12), 2724-2732. https://doi.org/10.1002/ijc.27816

Lung carcinogenesis by tobacco smoke

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