Anti‐tumor potential of retinoic acid: Stimulation of immune mediated effectors

Paul Q. Patek; John Leslie Collins; Ganesa Yogeeswaran; Gunther Dennert

doi:10.1002/ijc.2910240516

journal article Nov 15, 1979

Anti‐tumor potential of retinoic acid: Stimulation of immune mediated effectors

Paul Q. Patek John Leslie Collins Ganesa Yogeeswaran Gunther Dennert

International Journal of Cancer Vol. 24 No. 5 pp. 624-628 · Wiley

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Abstract

AbstractData are presented on the effects of retinoic acid (RA) treatment on the in vivo growth of tumors in two mouse strains. Inhibition of tumor growth as a result of systemic RA injection was observed in three out of seven tumor models. Using adult thymectomized, lethally irradiated and fetal liver (A × TFL) reconstituted mice, we found that inhibition of tumor growth is not due to direct toxic effects of RA but rather appears to be the result of stimulation of thymus‐dependent immune‐mediated effectors able to suppress tumor growth. Results suggest that only strongly immunogenic tumors are sensitive to in vivo retinoid inhibition.

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References

Details

Published: Nov 15, 1979
Vol/Issue: 24(5)
Pages: 624-628
License: View

Authors

Cite This Article

Paul Q. Patek, John Leslie Collins, Ganesa Yogeeswaran, et al. (1979). Anti‐tumor potential of retinoic acid: Stimulation of immune mediated effectors. International Journal of Cancer, 24(5), 624-628. https://doi.org/10.1002/ijc.2910240516

Anti‐tumor potential of retinoic acid: Stimulation of immune mediated effectors

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