Roles of the Hippo pathway in lung development and tumorigenesis

Benjamin Yeung; Jihang Yu; Xiaolong Yang

doi:10.1002/ijc.29457

journal article Feb 21, 2015

Roles of the Hippo pathway in lung development and tumorigenesis

Benjamin Yeung Jihang Yu

Xiaolong Yang

International Journal of Cancer Vol. 138 No. 3 pp. 533-539 · Wiley

View at Publisher Save 10.1002/ijc.29457

Abstract

Lung cancer is the most commonly diagnosed cancer and accounts for one fifth of all cancer deaths worldwide. Although significant progress has been made toward our understanding of the causes of lung cancer, the 5‐year survival is still lower than 15%. Therefore, there is an urgent need for novel lung cancer biomarkers and drug targets. The Hippo signaling pathway is an emerging signaling pathway that regulates various biological processes. Recently, increasing evidence suggests that the Hippo pathway may play important roles in not only lung development but also lung tumorigenesis. In this review article, we will summarize the most recent advances and predict future directions on this new cancer research field.

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Metrics

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Citations

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References

Details

Published: Feb 21, 2015
Vol/Issue: 138(3)
Pages: 533-539
License: View

Authors

B

Benjamin Yeung

Department of Pathology and Molecular Medicine Queen's University Kingston Ontario Canada

J

Jihang Yu

Department of Pathology and Molecular Medicine Queen's University Kingston Ontario Canada

X

Xiaolong Yang

Department of Pathology and Molecular Medicine Queen's University Kingston Ontario Canada

Funding

Canadian Institutes of Health Research (CIHR)

Cite This Article

Benjamin Yeung, Jihang Yu, Xiaolong Yang (2015). Roles of the Hippo pathway in lung development and tumorigenesis. International Journal of Cancer, 138(3), 533-539. https://doi.org/10.1002/ijc.29457

Roles of the Hippo pathway in lung development and tumorigenesis

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