Insulin‐Dependent Diabetes Affects Testicular Function by FSH‐ and LH‐Linked Mechanisms

Joan Ballester; M. Carmen Muñoz; Jorge Domínguez; Teresa Rigau; Joan J. Guinovart; Joan E. Rodríguez‐Gil

doi:10.1002/j.1939-4640.2004.tb02845.x

journal article Sep 10, 2004

Insulin‐Dependent Diabetes Affects Testicular Function by FSH‐ and LH‐Linked Mechanisms

Joan Ballester

M. Carmen Muñoz

Jorge Domínguez Teresa Rigau Joan J. Guinovart Joan E. Rodríguez‐Gil

Journal of Andrology Vol. 25 No. 5 pp. 706-719 · Wiley

View at Publisher Save 10.1002/j.1939-4640.2004.tb02845.x

Abstract

ABSTRACT: A study was conducted to form a unified hypothesis regarding the gonadotropin‐related mechanisms that underlie alterations in the male reproductive system in individuals with diabetes. Streptozotocin‐induced diabetes resulted in reduced fertility, prolificacy, and libido. Testes showed a marked decrease in the number and function of Leydig cells, the latter manifested as changes in the expression of biochemical markers, including the GLUT‐3 hexose transporter, c‐kit, insulin‐like growth factor I (IGF‐I), androgen receptors, and overall tyrosine phosphorylation, as assessed by Western blot and immunocytochemical analyses. The expression of c‐kit, IGF‐I, insulin, and follicle‐stimulating hormone (FSH) receptors in the seminiferous tubules was also affected. Serum levels of luteinizing hormone (LH), FSH, and testosterone significantly decreased. There was a significant (P < .05) correlation between the serum levels of insulin and FSH. No significant correlation was found between the serum levels of insulin or glucose and LH. On the basis of our results, we conclude that, in insulin‐dependent diabetes, 1) Leydig cell function and testosterone production decrease because of the absence of the stimulatory effect of insulin on these cells and an insulin‐dependent decrease in FSH, which, in turn, reduces LH levels; and 2) sperm output and fertility are reduced because of a decrease in FSH caused by a reduction in insulin.

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References

Details

Published: Sep 10, 2004
Vol/Issue: 25(5)
Pages: 706-719
License: View

Authors

Departament de Física Aplicada Universitat Politècnica de València Camino de Vera s/n 46022 València Spain

Departament de Medicina i Cirurgia Animal, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain

J

Joan J. Guinovart

Institute for Research in Biomedicine (IRB Barcelona) Barcelona The Barcelona Institute of Science and Technology Baldiri Reixac 10 Barcelona 08028 Spain; Department of Biochemistry and Molecular Biology University of Barcelona Av. Diagonal 643 Barcelona 08028 Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) Madrid Spain

J

Joan E. Rodríguez‐Gil

Cite This Article

Joan Ballester, M. Carmen Muñoz, Jorge Domínguez, et al. (2004). Insulin‐Dependent Diabetes Affects Testicular Function by FSH‐ and LH‐Linked Mechanisms. Journal of Andrology, 25(5), 706-719. https://doi.org/10.1002/j.1939-4640.2004.tb02845.x

Insulin‐Dependent Diabetes Affects Testicular Function by FSH‐ and LH‐Linked Mechanisms

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